放射化学治疗协同贞芪六君解毒颗粒治疗局部晚期子宫颈癌的临床研究  

Clinical Research on Concurrent Chemoradiotherapy Combined with Zhenqi Liujun Jiedu Granule in the Treatment of Locally Advanced Cervical Cancer

作　　者：何慧 杨忠明 李华伟 赵彪[1] 付洪芳 刘福蓉 高彩玉 田园 陈国芳 He Hui;Yang Zhongming;Li Huawei;Zhao Biao;Fu Hongfang;Liu Furong;Gao Caiyu;Tian Yuan;Chen Guofang(Department of Integrative Medicine,Sichuan Cancer Hospital,Chengdu 610041,China;Department of Oncology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Department of Oncology,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,China)

机构地区：[1]四川省肿瘤医院中西医结合科,成都610041 [2]西南医科大学附属医院肿瘤科,泸州646000 [3]西南医科大学附属中医医院肿瘤科,泸州646000

出　　处：《成都医学院学报》2025年第2期275-277,282,共4页Journal of Chengdu Medical College

基　　金：四川省科学技术厅重点研发项目(No:2022YFS0397)。

摘　　要：目的 探讨局部晚期子宫颈癌放射化学治疗(以下简称“放化疗”)协同贞芪六君解毒颗粒治疗的近期疗效以及放化疗的不良反应,从而更好地指导临床治疗。方法 选择2022年1月至2024年6月四川省肿瘤医院与西南医科大学附属中医医院接受同步放化疗与后装放射治疗初治的局部晚期子宫颈癌患者共168例,随机分为试验组和对照组,每组84例,两组均接受直线加速器放疗与后装放射治疗及化疗,其中化疗药物选择顺铂25 mg/m2,每周1次静脉滴注;试验组在治疗第1天给予贞芪六君解毒颗粒口服,1剂/d,连服至治疗结束。研究终点包括两组患者治疗的近期疗效、放射性炎症反应、其他不良反应及体力状况。结果 两组患者近期疗效评价和客观反应率(ORR)差异无统计学意义(P>0.05),疾病控制率(DCR)评价差异无统计学意义(P>0.05);两组患者放射性宫颈炎、膀胱炎、直肠炎与皮肤炎比较差异有统计学意义(P<0.05),消化道、骨髓等不良反应比较差异有统计学意义(P<0.01);两组患者治疗后karnofsky评分比较,差异有统计学意义(P<0.05)。结论 贞芪六君解毒颗粒虽然不能提高局部晚期子宫颈癌放化疗与后装放射治疗近期疗效,但可减轻放射炎症与消化道不良反应及骨髓抑制程度,改善患者体力状况,提高患者生活质量且安全性较好。Objective To observe the short-term efficacy of concurrent chemoradiotherapy(CCRT)and brachytherapy combined with Zhenqi Liujun Jiedu Granule(ZLJG)in the treatment of patients with locally advanced cervical cancer(LACC),as well as the adverse reactions of CCRT,so as to provide better guidance for clinical treatment.Methods A total of 168 cases with LACC who received CCRT and brachytherapy for initial treatment in Sichuan Cancer Hospital and the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University from January 2022 to June 2024 were selected.They were randomly divided into an experimental group(n=84)and a control group(n=84).Both groups received CCRT,brachytherapy,and weekly chemotherapy with cisplatin 25 mg/m 2,while the experimental group was additionally given ZLJG one dose per day until the end of treatment.The short-term efficacy,radiation-induced inflammatory reactions,adverse reactions,and physical condition of patients[assessed by Karnofsky Performance Status(KPS)]were observed.Results There was no significant difference in short-term efficacy,objective response rate(ORR),and disease control rate(DCR)between the two groups(P>0.05).There were statistically significant differences in radiation cervicitis,cystitis,proctitis and dermatitis,in adverse reactions of digestive tract and bone marrow,and in KPS scores between the two groups(P<0.05).Conclusion ZLJG can not increase the short-term efficacy of CCRT and brachytherapy in the treatment of LACC.However,it can reduce radiation-induced inflammatory reactions and bone marrow suppression,improve the physical condition and the quality of life of patients,with good safety.

关 键 词：贞芪六君解毒颗粒 局部晚期子宫颈癌 放射化学治疗 顺铂 近期疗效 

分 类 号：R734.2[医药卫生—肿瘤]