血清sB7-H3、DOK3对胃癌患者术后复发的预测价值  

Predictive Value of Serum sB7-H3 and DOK3 for Postoperative Recurrence in Gastric Cancer Patients

作　　者：魏利敏[1] 王光辉[1] 雷海阁 王云阁 Wei Limin;Wanng Guanghui;Lei Haige;Wang Yunge(Department of General Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Northwest University First Hospital,Xi'an 710043,China;Department of Disinfection and Supply,Northwest University First Hospital,Xi'an 710043,China)

机构地区：[1]西安交通大学第一附属医院普通外科,西安710061 [2]西北大学第一医院,西安710043 [3]西北大学第一医院消毒供应室,西安710043

出　　处：《成都医学院学报》2025年第2期317-320,326,共5页Journal of Chengdu Medical College

摘　　要：目的 探讨血清可溶性B7-H3(sB7-H3)、对接蛋白3(DOK3)对胃癌患者术后复发的预测价值。方法 选取2020年3月至2022年3月西安交通大学第一附属医院收治的胃癌患者94例为胃癌组,另选取同期健康体检者94例为对照组。采用酶联免疫吸附测定法(ELISA)测定血清sB7-H3、DOK3表达水平;采用多因素Logistic回归分析胃癌患者术后复发的影响因素;绘制ROC曲线分析血清sB7-H3、DOK3对胃癌患者术后复发的预测价值。结果 与对照组相比,胃癌组患者血清sB7-H3表达水平升高(P<0.05),DOK3表达水平降低(P<0.05)。复发组与未复发组相比,远处转移差异有统计学意义(P<0.05)。与未复发组相比,复发组患者血清sB7-H3表达水平升高(P<0.05),DOK3表达水平降低(P<0.05)。多因素Logistic回归分析结果显示,sB7-H3、远处转移是影响胃癌术后复发的危险因素(P<0.05),DOK3是影响胃癌术后复发的保护因素(P<0.05)。ROC结果显示,血清sB7-H3、DOK3二者联合预测胃癌患者术后复发的AUC最高为0.848,优于血清sB7-H3、DOK3各自单独预测的0.696和0.750(P<0.05)。结论 胃癌患者血清sB7-H3表达水平升高,DOK3表达水平降低,二者联合可更好地预测胃癌患者术后复发。Objective To explore the predictive value of serum soluble B7-H3(sB7-H3)and adaptor protein downstream of Kinase 3(DOK3)for postoperative recurrence in gastric cancer patients.Methods Ninety-four patients with gastric cancer admitted to the First Affiliated Hospital of Xi'an Jiaotong University from March 2020 to March 2022 were selected as the gastric cancer group,and another 94 healthy individuals who underwent physical examinations were included as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to determine the expression levels of serum sB7-H3 and DOK3.Multivariate Logistic regression was utilized to analyze the influencing factors of postoperative recurrence in gastric cancer patients.Receiver operator characteristic(ROC)curve was plotted to analyze the predictive value of serum sB7-H3 and DOK3 for postoperative recurrence in gastric cancer patients.Results Compared with the control group,the gastric cancer group exhibited increased serum sB7-H3 level(P<0.05)but reduced serum DOK3 level(P<0.05).There was significant difference in distant metastasis between the recurrent group and the non-recurrent group(P<0.05).Compared with the non-recurrence group,the recurrence group showed increased serum sB7-H3 level(P<0.05)but reduced serum DOK3 level(P<0.05).Multivariate logistic regression found that sB7-H3 and distant metastasis were risk factors for postoperative recurrence of gastric cancer(P<0.05),while DOK3 was a protective factor for postoperative recurrence of gastric cancer(P<0.05).The ROC results showed that the highest area under the curve(AUC)of the combined detection of serum sB7-H3 and DOK3 in predicting postoperative recurrence of gastric cancer patients was 0.848,which was better than 0.696 and 0.750 of serum sB7-H3 and DOK3,respectively(P<0.05).Conclusion The expression level of serum sB7-H3 in gastric cancer patients increases,while the expression level of serum DOK3 decreases.The combination of the two can better predict postoperative recurrence in gastric cancer patients.

关 键 词：可溶性B7-H3 对接蛋白3 胃癌 复发 预测 

分 类 号：R735.2[医药卫生—肿瘤]