补体系统与种植体周围骨改建关系的研究进展  

Research progress of the relatioship between the complement system and peri-implant bone remodeling

作　　者：吴东远 陈思宇 吴琳[1] 刘笑涵[1] WU Dongyuan;CHEN Siyu;WU Lin;LIU Xiaohan(Department of Prosthodontics,School and Hosptial of Stomatology,China Medical University,Liaoning Provincal Key Laboratory of Oral Diseases,Shenyang 110002,China)

机构地区：[1]中国医科大学口腔医学院·附属口腔医院修复科,辽宁省口腔疾病重点实验室,沈阳110002

出　　处：《中国医科大学学报》2025年第3期262-267,共6页Journal of China Medical University

基　　金：国家自然科学基金(82201104);辽宁省教育厅科学研究经费项目(LJKZ0780);辽宁省教育厅基本科研项目(LJKMZ20221136)。

摘　　要：免疫微环境在种植体周围骨改建过程中发挥重要作用。补体系统是机体免疫系统的重要组成部分,对骨生成和骨吸收均有重要影响。然而,种植体植入不同时期以及不同种植体材料会以不同方式激活补体系统。本文总结了补体系统及其激活途径、补体系统对骨改建的影响、种植体植入不同时期以及不同种植体材料对补体系统激活的影响的研究进展,为通过靶向调控种植体周围补体微环境、促进骨改建提供参考。The immune microenvironment plays a crucial role in bone remodeling around implants.The complement system,a key component of the immune system,significantly influences bone formation and resorption.However,the activation of the complement system varies depending on the stages of implant placement and the types of implant materials.This review discusses the complement system,its activation pathways,its effects on bone remodeling,and the impact of various stages of implant placement and different materials on complement system activation.These insights would help develop strategies for promoting bone remodeling around implants through targeted regulation of the complement microenvironment in the vicinity of the implanted material.

关 键 词：补体 骨生成 骨吸收 种植体材料 

分 类 号：R783.4[医药卫生—口腔医学]