MTERF家族蛋白质的功能及其在恶性肿瘤发生发展中的作用研究进展  

Research progress on the function of MTERF family proteins and their roles in the occurrence and progres-sion of malignant tumors

作　　者：林亚茹(综述) 余敏[2] 熊伟(审校) LIN Yaru(reviewing);YU Min;XIONG Wei(checking)(College of Basic Medical Sciences,Key Laboratory of Clinical Biochemistry in Yunnan Provincial Universities,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,College of Pharmacy,Dali University,Dali 671000,Yunnan,China;College of Life Sciences,Yunnan University,Kunming 650091,Yunnan,China)

机构地区：[1]大理大学基础医学院,云南省高校临床生物化学检验重点实验室,云南省昆虫生物医药研发重点实验室,大理671000 [2]云南大学生命科学学院,昆明650091

出　　处：《医学研究与战创伤救治》2025年第2期202-207,共6页Journal of Medical Research & Combat Trauma Care

基　　金：国家自然科学基金(32160167,82160516);云南省教育厅科学研究基金(2024Y875)。

摘　　要：人线粒体转录终止因子(MTERFs)家族成员在调控线粒体功能中发挥重要作用,通过控制线粒体DNA(mtDNA)复制、转录和翻译,甚至参与线粒体核糖体亚基组装和蛋白质合成,影响线粒体代谢和细胞能量产生。先前研究表明,MTERF家族蛋白不仅参与了正常细胞的生理功能,还广泛参与人类恶性肿瘤的发生发展,与肿瘤细胞的增殖、迁移和侵袭等生物学行为有关,对肿瘤患者的预后评估和治疗具有重要意义。文章主要从MTERF家族各成员在肿瘤中的功能和作用机制方面进行综述。Members of the human mitochondrial transcription termination factors(MTERFs)family play an important role in the regulation of mitochondrial function,affecting mitochondrial metabolism and cell energy production by controlling mitochondrial DNA(mtDNA)replication,transcription and translation,and even participating in mitochondrial ribosome subunit assembly and protein synthesis.Previous studies have shown that MTERF family proteins not only participate in the physiological function of normal cells,but also widely participate in the occurrence and development of human malignant tumors,and are related to the biological behaviors of tumor cell proliferation,migration and invasion,which is of great significance for the prognosis assessment and treatment of tumor patients.This article mainly reviews the function and mechanism of MTERF family members in tumor.

关 键 词：线粒体 线粒体转录终止因子 蛋白家族 恶性肿瘤 预后 

分 类 号：R730[医药卫生—肿瘤]