Physicians'risk and time preferences and their willingness to detect and disclose genomic secondary findings:A multiple price list experiment  

作　　者：Shan Jiang Haiyin Wang Zhuo Chen Xiao Zang Yawen Jiang Zhongliang Zhou Yuanyuan Gu 

机构地区：[1]Macquarie University Centre for the Health Economy,Macquarie Business School and Australian Institute of Health Innovation,Macquarie University,Sydney,2109,Australia [2]Shanghai Health Development Research Centre,Shanghai,201199,China [3]Departnent of Health Policy and Management,College of Public Health,University of Georgia,Athens,GA,30602,USA [4]Scholof Economics,Faculty of Humanities and Social Sciences,University of Nottingham Ningbo China,Ningbo,Zhejiang,3100,China [5]Division of Health Policy and Management,University of Minnesota Twin Cities,Minneapolis,MN,55455,USA [6]school of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen,Guangdong,518107,China [7]School of Public Policy and Administration,Xian Jiaotong University,Xian,710049,China

出　　处：《Pharmacoeconomics and Policy》2025年第1期25-32,共8页药物经济与政策(英文)

摘　　要：To quantify physicians'risk and time preferences and explore the association between the preferences and their willingness to detect and disclose secondary findings(SFs)derived from genome-scale sequencing.We designed a webbased survey incorporating a multiple price list(MPL)as the instrument for risk and time preference measurement.The estimation was under the expected utility theory(EUT)and rank dependent utility(RDU)frameworks,respectively.The isoelastic and power function utility models were applied.We received responses from 87 physicians,among whom 46 completed the questionnaire(a completion rate of 52.9%).We observed positive risk-aversion coefficients under EUT(0.33,95%CI 0.15-0.51)and RDU(0.51,95%CI 0.32-0.71),suggesting that physicians were generally risk-averse.Respondents were likely to underestimate probabilities of low to moderate levels,and slightly overestimate high-level probabilities.Physicians supporting the detection and disclosure of SFs had a larger risk-aversion coefficient and a smaller discounting parameter than the non-supporters,suggesting that they were more risk-averse and discounted future utility less.Assuming heterogeneous risk perception,we found respondents underestimated low/moderate risk and slightly overestimated high risk.This study indicates that physicians who are risk-averse and discount future utility slightly are willing to detect and return SFs.The findings contribute to the debate surrounding SF disclosure and generate implications for shared decision-making in clinical genome-scale sequencing.

关 键 词：Risk preference Time preference Behavioural economics Secondary findings Genome sequencing 

分 类 号：R73[医药卫生—肿瘤]