Angiogenesis:the Yin and Yang in intrahepatic cholangiocarcinoma  

作　　者：Adriana Romanzi Erica Villa 

机构地区：[1]Department of Biomedical,Metabolic and Neural Sciences,Clinical and Experimental Medicine PhD Program,University of Modena and Reggio Emilia,Modena 41125,Italy [2]Chimomo Department,Gastroenterology Unit,University of Modena and Reggio Emilia and University Hospital of Modena,Modena 41125,Italy

出　　处：《Hepatoma Research》2023年第1期136-148,共13页肝癌研究(英文版)

基　　金：supported by Associazione Italiana sulla Ricerca sul Cancro(AIRC;Grant No.IG 2020-ID.24858 project-P.I.Villa Erica).

摘　　要：The tumor microenvironment(TME)constitutes a complex structure comprising different cell types and soluble factors that surround the tumor and promote its progression.Primarily for its pivotal role in malignant growth,TME has become a potential therapeutic objective for developing new targeted therapy and a marker for assessing therapeutic response.In intrahepatic cholangiocarcinoma(iCCA),the second most common primary liver malignancy,TME has also gained a central role in understanding the mechanisms underlying tumor progression.In this review,we focused on the role of angiogenic factors and their pathway in iCCA and analyzed possible therapeutic and prognostic implications.

关 键 词：Intrahepatic cholangiocarcinoma angiogenic factors VEGF ANGIOPOIETINS thrombospondin 1 ENDOTHELINS 

分 类 号：R73[医药卫生—肿瘤]