Cholangiocarcinoma tumor microenvironment highlighting fibrosis and matrix components  

作　　者：Alessandra Caligiuri Maurizio Parola Fabio Marra Stefania Cannito Alessandra Gentilini 

机构地区：[1]Department of Experimental and Clinical Medicine,University of Florence,Florence 50139,Italy [2]Department of Clinical and Biological Sciences,Unit of Experimental Medicine and Clinical Pathology,University of Torino,Torino 10125,Italy

出　　处：《Hepatoma Research》2023年第1期267-288,共22页肝癌研究(英文版)

摘　　要：Cholangiocarcinoma(CCA)is an extremely aggressive malignancy characterized by a very limited prognosis and scarce treatment options.The majority of patients are diagnosed at an advanced stage and do not qualify for potentially curative surgical treatments,making CCA an increasingly prevalent global challenge.CCA is characterized by a highly reactive desmoplastic stroma,with complex mechanisms underlying the mutual interactions between tumor cells and stromal compartment.This review focuses on the recent studies examining CCA’s biological features,with particular reference to the tumor reactive stroma(TRS)and its role in CCA progression,including matrix remodeling,angiogenesis and lymphangiogenesis,metastasis,and immune evasion.After giving a panoramic view of the relationship between the tumoral and stromal compartment(cancer-associated fibroblast,CAFs and tumor-associated macrophages,TAMs),this review also discusses the current therapeutic approaches to counteract CAFs and TAMs effects on CCA progression.

关 键 词：Tumor microenvironments CAFs TAMS CCA tumor-reactive stroma therapeutic target INTRODUCTION 

分 类 号：R73[医药卫生—肿瘤]