Combined hepatocellular-cholangiocarcinoma:morpho-molecular updates and considerations  

作　　者：Naghia Ahmed Francesca Falcinelli Margherita Rimini Valentina Burgio Andrea Casadei-Gardini Luca Aldrighetti Francesca Ratti Federica Pedica 

机构地区：[1]Pathology Unit,Istituto Clinico S.Anna,Brescia 25123,Italy [2]Pathology Unit,Vita-Salute San Raffaele University,Milan 20132,Italy [3]IRCCS San Raffaele Scientific Institute Hospital,Department of Oncology,Vita-Salute San Raffaele University,Milan 20132,Italy [4]Hepatobiliary Surgery Division,Liver Center,Vita-Salute San Raffaele University,IRCCS San Raffaele Scientific Institute,Milan 20132,Italy

出　　处：《Hepatoma Research》2023年第1期414-425,共12页肝癌研究(英文版)

摘　　要：Combined Hepatocellular-Cholangiocarcinoma is a heterogenous primary malignant epithelial tumor of the liver with variable morphological and immunophenotypical features.Although the biology of this tumor has been described in the literature,changes in classification and its heterogeneity imply difficulties in collecting reliable homogenous groups to compare.The article aims to review available data on morphology and immunohistochemistry for practicing pathologists integrated with original data from our referral Center.

关 键 词：Combined hepatocellular-cholangiocarcinoma WHO classification IMMUNOHISTOCHEMISTRY molecular analyses 

分 类 号：R73[医药卫生—肿瘤]