Liver venous deprivation(LVD)before extended hepatectomy:a French multicentric retrospective cohort  

作　　者：Mehdi Boubaddi Arthur Marichez Florian Pecquenard Charlotte Maulat Emmanuel Buc Laurent Sulpice Ahmet Ayav Stéphanie Truant Fabrice Muscari Laurence Chiche Christophe Laurent 

机构地区：[1]Hepatobiliary and Pancreatic Surgery Department,CHU de Bordeaux,Pessac,France [2]Hepatobiliary and Pancreatic Surgery Department,CHU de Lilles,Lille,France [3]Hepatobiliary and Pancreatic Surgery Department,CHU de Toulouse,Toulouse,France [4]Hepatobiliary and Pancreatic Surgery Department,CHU de Clermont-Ferrand,Clermont-Ferrand,France [5]Hepatobiliary and Pancreatic Surgery Department,CHU de Rennes,Rennes,France [6]Hepatobiliary and Pancreatic Surgery Department,CHU de Nancy,Nancy,France

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第6期937-949,I0001,共14页肝胆外科与营养(英文)

摘　　要：Background:Post-hepatectomy liver failure(PHLF)is the first cause of death after major hepatectomy,and future liver remnant(FLR)volume is the main factor predicting PHLF.Liver venous deprivation(LVD)via portal and hepatic vein embolization has been suggested to induce a better hypertrophy of the FLR than portal vein embolization.The aim of this retrospective multicentric study was to assess safety,feasibility and efficacity of LVD in a French national multicentric register.Methods:Between 2016 and 2023,LVD was performed in 7 expert centers,for patients with liver malignancies requiring major hepatectomy with an FLR percentage of total liver volume(FLR%)≤25%for a healthy liver or<30%for a diseased liver.FLR volumetry was assessed before and 4 weeks after the procedure.Results:One hundred and ninety-two patients were included in the study.The technical success rate was 100%and severe complication rate post-LVD was 2.6%(5/192).The FLR%increased by 61.7%over an average of 27±9.7 days.Major hepatectomy was performed 40 days after LVD on 161(83.8%)patients.Hepatectomy was not performed on 31(16.2%)patients,mostly because of oncological progression.Severe postoperative complications(Clavien-Dindo grade≥IIIA)occurred in 21.1%(34/161)of patients.Postoperative mortality rate was 4.3%(7/161).Conclusions:This study is the largest to confirm that LVD is a safe,reproducible,efficient technique that induces rapid major FLR growth.However,this new technique needs to be standardized and harmonized between centers to ensure uniform results.

关 键 词：Liver venous deprivation(LVD) post-hepatectomy liver failure(PHLF) HEPATECTOMY liver hypertrophy 

分 类 号：R73[医药卫生—肿瘤]