TyG指数联合红细胞压积对伴高甘油三酯血症重症急性胰腺炎的早期预测价值  

The Early Prediction Value of TyG Index Combined with Hematocrit for Severe Acute Pancreatitis with Hypertriglyceridemia

作　　者：卢俊竹 陈文喧 杨发俊 陈壁钦 LU Jun-zhu;CHEN Wen-xuan;YANG Fa-jun;CHEN Bi-qin(Department of gastroenterology and general medicine of Jieyang People's Hospital,Guangdong,522000;不详)

机构地区：[1]广东省揭阳市人民医院消化内科,522000 [2]广东省揭阳市人民医院全科医学科,522000

出　　处：《岭南急诊医学杂志》2025年第1期8-10,21,共4页Lingnan Journal of Emergency Medicine

摘　　要：目的:评估甘油三酯-葡萄糖(TyG)指数联合红细胞压积(HCT)对伴高甘油三酯血症重症急性胰腺炎(SAP)的早期预测价值。方法:收集2023年1月至2024年5月揭阳市人民医院消化内科甘油三酯高于正常的急性胰腺炎(AP)患者229例。按病情分为轻症(114例)、中度重症(61例)、重症(54例)三组。24 h内采集外周血,检测甘油三酯(TG)、血糖(GLU)、HCT等指标,完善CT检查,计算TyG指数,对三组间一般资料进行比较。筛选SAP的早期危险因素,绘制ROC曲线,计算TyG指数和HCT的最佳阈值。最后计算TyG指数-HCT,绘制ROC曲线研究其对SAP的早期预测价值。结果:TyG指数[OR=2.924,95%CI(1.919,4.455),P<0.001]和HCT[OR=1.078,95%CI(1.004,1.156),P=0.037]是伴高甘油三酯血症SAP的早期危险因素,TyG指数和HCT的AUC分别为0.774和0.663。TyG指数的最佳阈值为11.885,敏感度63.0%,特异度80.0%,HCT的最佳阈值为46.1,敏感度55.6%,特异度72.0%。比较TyG指数-HCT、TyG指数和HCT的AUC,其中TyG指数-HCT的AUC最大,为0.798。结论:TyG指数和HCT对伴高甘油三酯血症AP患者就诊24 h内发展为SAP具有预测价值,TyG指数-HCT联合对SAP的早期预测价值更高。Objective:To explore the early prediction value of triglyceride‐glucose(TyG)index combined with hematocrit(HCT)for severe acute pancreatitis(SAP)with hypertriglyceridemia.Methods:A total of 229 acute pancreatitis(AP)patients with hypertriglyceridemia were collected in the Gastroenterology Department of Jieyang Peoples Hospital from January 2023 to May 2024.Patients were assigned to 3 groups according to the severity of AP:the mild group(n=114),moderately severe group(n=61),and severe group(n=54).The peripheral blood was taken in all patients within 24 h after hospital admission.Triglyceride(TG),blood glucose(GLU),HCT were detected,CT imaging were completed.TyG index who was calculated and HCT were compared among the three groups.The early risk factors of SAP with hypertriglyceridemia were screened,and the ROC curve was drawn to calculate the optimal thresholds of TyG index and HCT.Finally,TyG index‐HCT was calculated,and the ROC curve was drawn to study the predictive value of TyG index‐HCT for SAP.Results:TyG index[OR=2.924,95%CI(1.919,4.455),P<0.05]and HCT[OR=1.078,95%CI(1.004,1.156),P<0.05]were early risk factors for SAP with hypertriglyceridemia.The AUC of TyG index and HCT were 0.774 and 0.663.The optimal threshold,sensitivity and specificity of TyG index were 11.885,63.0%and 80.0%,and the optimal threshold,sensitivity and specificity of HCT were 46.1,55.6%and 72.0%.The AUC of TyG index‐HCT(0.798)was the largest.Conclusion:TyG index and HCT have predictive value for SAP progression within 24 h of hospital admission in AP with hypertriglyceridemia.TyG index‐HCT combined detection have early predictive value for SAP.

关 键 词：甘油三酯-葡萄糖指数 红细胞压积 高甘油三酯血症 重症急性胰腺炎 

分 类 号：R57[医药卫生—消化系统]