神经质与炎症性肠病的因果关联:一项两样本孟德尔随机化研究  

The Causal Association Between Neuroticism and Inflammatory Bowel Disease:A Two⁃sample Mendelian Randomization Study

作　　者：张娜[1] 帕丽莎•阿里木 顾杨 余涛[1] 李莉[1] ZHANG Na;PALISHA Alimu;GU Yang;YU Tao;LI Li(Department of Emergency medicine,the Sun Yat-sen Memorial Hospital,Guangzhou,Guangdong,510120)

机构地区：[1]中山大学孙逸仙纪念医院急诊科,510120

出　　处：《岭南急诊医学杂志》2025年第1期18-21,共4页Lingnan Journal of Emergency Medicine

摘　　要：目的:利用孟德尔随机化探究两样本神经质与炎症性肠病的风险关联。方法:通过公开发表的全基因组关联研究数据库获取关于炎症性肠病的数据集,采用逆方差加权法(IVW)、MR-Egger回归法、加权中位数法(WME)、简单模型和加权模型共5个回归模型进行MR分析,以IVW为主要分析方法,提取与炎症性肠病强相关的单核苷酸多态性作为工具变量,验证神经质和炎症性肠病的因果关系,并利用Cochrane's Q、MREgger、Leave-one-out检验工具变量的异质性、水平多效性、敏感性,以评估结果的可靠性和稳定性。结果:逆方差分析结果显示神经质增加炎症性肠病的患病风险(OR=1.15,95%CI:1.09~1.21,P<0.01)。异质性检验显示两样本间不存在异质性;水平多效性分析示本研究所纳SNP均不具有水平多效性;敏感性分析结果显示依次剔除各单核苷酸多效性(SNP)后,神经质与炎症性肠病风险间的正向因果关系仍稳健。结论:神经质与炎症性肠病之间存在稳定的正向因果关联,这提示对于IBD患者心理支持和治疗的必要性。Objective:To explore the risk association between neuroticism and inflammatory bowel disease using Mendelian randomization.Methods:Data on inflammatory bowel disease were obtained from publicly available genomewide association study databases.Five regression models including inverse variance weighted(IVW),MR‐Egger regression,weighted median estimation(WME),simple model,and weighted model were used for MR analysis,with IVW as the primary analysis method.Single nucleotide polymorphisms strongly associated with inflammatory bowel disease were extracted as instrumental variables to validate the causal relationship between neuroticism and inflammatory bowel disease.Cochrane's Q,MR‐Egger,and Leave‐one‐out tests were used to assess the heterogeneity,horizontal pleiotropy,and sensitivity of the instrumental variables,in order to evaluate the reliability and stability of the results.Results:The inverse variance analysis revealed that neuroticism increases the risk of inflammatory bowel disease(OR=1.15,95%CI:1.09~1.21,P<0.01).Heterogeneity tests showed no heterogeneity between the two samples;horizontal pleiotropy analysis indicated that the included SNPs did not exhibit horizontal pleiotropy.Sensitivity analysis results showed that the positive causal relationship between neuroticism and the risk of inflammatory bowel disease remained robust after sequentially removing each single nucleotide polymorphism(SNP).Conclusion:There is a stable positive causal association between neuroticism and inflammatory bowel disease,which suggests the necessity of psychological support and treatment for IBD patients.

关 键 词：孟德尔随机化 神经质 炎症性肠病 

分 类 号：R574[医药卫生—消化系统]