香丹注射液联合倍他司汀对急性脑梗死患者NIHSS、ADL评分及血清CRP、PCT水平的影响  

Effects of Xiangdan injection combined with betahistine on NIHSS and ADL scores and serum CRP and PCT levels in patients with acute cerebral infarction

作　　者：李月娟 黄玮[1] 李书恒[1] 姜广亚[1] 王瑞恒 陈鑫 刘飞宏 韩小辉[1] Li Yuejuan;Huang Wei;Li Shuheng;Jiang Guangya;Wang Ruiheng;Chen Xin;Liu Feihong;Han Xiaohui(Yellow River Central Hospital,Yellow River Water Conservancy Commission,Zhengzhou 450000,Henan Province)

机构地区：[1]黄河水利委员会黄河中心医院,河南郑州450000

出　　处：《辽宁医学杂志》2025年第1期49-52,共4页Medical Journal of Liaoning

摘　　要：目的探讨香丹注射液联合倍他司汀在急性脑梗死(Acutecerebralinfarction,ACI)治疗中的应用价值。方法回顾性选取2021年6月至2023年6月我院收治(符合纳入标准)的86例ACI患者作为研究对象,按不同治疗方案分为参照组(n=43)、观察组(n=43)。两组均予以常规干预(溶栓、营养脑神经等)治疗,参照组予以倍他司汀治疗,观察组予以香丹注射液联合倍他司汀治疗。比较两组治疗前、治疗2周后血流动力学指标[全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)]水平、美国国立卫生院卒中量表(NIHSS)评分、日常生活能力、血清因子指标[C反应蛋白(CRP)、降钙素原(PCT)]水平及不良反应发生率。结果观察组治疗2周后HBV、LBV、PV水平均低于参照组(P<0.05);观察组治疗2周后NIHSS评分、ADL评分改善幅度均大于参照组(P<0.05);观察组治疗2周后CRP、PCT水平均低于参照组(P<0.05);观察组不良反应总发生率(9.30%)与参照组(4.65%)相比,差异无统计学意义(P>0.05)。结论香丹注射液联合倍他司汀治疗相较于单用倍他司汀治疗对ACI患者机体炎症状态、神经功能缺损程度的改善效果更为显著,更利于提升其日常生活能力,促进预后恢复。Objective To investigate the clinical value of Xiangdan injection combined with betahistine in the treatment of Acutecerebralinfarction(ACI).Methods A total of 86 patients with ACI admitted to our hospital from June 2021 to June 2023(meeting the inclusion criteria)were retrospectively selected as the study objects,and divided into the reference group(n=43)and the observation group(n=43)according to different treatment regimens.Both groups were treated with routine intervention(thrombolysis,nutrition of the brain nerve,etc.),the reference group was treated with betahistine,and the observation group was treated with Xiangdan injection combined with betahistine.Hemodynamic indexes[whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),plasma viscosity(PV)],National Institutes of Health Stroke Scale(NIHSS)score,ability of daily living,serum factor index[C-reactive protein(CRP),procalcitonin(PCT)]levels and incidence of adverse reactions were compared between the two groups before treatment and 2 weeks after treatment.Results HBV,LBV and PV levels in observation group were lower than those in reference group after 2 weeks of treatment(P<0.05).After 2 weeks of treatment,the improvement of NIHSS score and ADL score in observation group was greater than that in reference group(P<0.05).After 2 weeks of treatment,CRP and PCT levels in observation group were lower than those in reference group(P<0.05);There was no significant difference in the total incidence of adverse reactions between the observation group(9.30%)and the reference group(4.65%)(P>0.05).Conclusion Compared with betahistine alone,Xiangdan injection combined with betahistine has a more significant effect on the improvement of inflammation and neurological impairment in ACI patients,and is more conducive to improving their daily living ability and promoting prognosis recovery.

关 键 词：香丹注射液 倍他司汀 急性脑梗死 NIHSS评分 ADL评分 炎症因子 

分 类 号：R74[医药卫生—神经病学与精神病学]