脑小血管病认知障碍与脑白质高信号分级及脑萎缩分级相关研究  

The study on the correlation between cognitive impairment of cerebral small vessel disease and white matter hyperintensity grade and cerebral atrophy grade

作　　者：刘婷 职瑾[2] 刘仲仲[3] 王芳[2] 孟凤珠 蔺雪梅[4,5] 王燕 LIU Ting;ZHI Jin;LIU Zhongzhong;WANG Fang;MENG Fengzhu;LIN Xuemei;WANG Yan(Department of Radiology,Xi’an No.1 Hospital,Xi’an 710002,China;Department of Geriatric Neurology,Xi’an No.1 Hospital,Xi’an 710002,China;Department of Geriatrics,Xi’an No.1 Hospital,Xi’an 710002,China;Department of Neurology,Xi’an No.1 Hospital,Xi’an 710002,China;Xi’an Key Laboratory of Innovation and Translation of Neuroimmunological Diseases,Xi’an 710002,China)

机构地区：[1]西安市第一医院影像科,陕西西安710002 [2]西安市第一医院老年神经内科,陕西西安710002 [3]西安市第一医院老年病研究室,陕西西安710002 [4]西安市第一医院神经内科,陕西西安710002 [5]西安市神经免疫疾病创新转化重点实验室,陕西西安710002

出　　处：《实用放射学杂志》2025年第1期1-4,共4页Journal of Practical Radiology

基　　金：西安市卫生健康委员会科研项目(2020yb06)。

摘　　要：目的探讨脑小血管病(CSVD)认知障碍与脑白质高信号分级及脑萎缩分级之间的相关性。方法回顾性分析213例CSVD患者资料,采用头颅MR检查半定量Fazekas直观评分评估脑白质高信号,全脑皮层萎缩分级评价脑萎缩情况。使用认知功能评估工具包括简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)对每位患者进行评估。比较不同Fazekas分级及脑萎缩分级患者之间MMSE及MoCA评分的差异。结果不同性别CSVD患者的年龄有统计学差异(P=0.04,t=4.288),男性平均年龄[(66.5±10.3)岁]小于女性[(69.5±10.0)岁]。不同性别患者与高血压病史之间有统计学差异(P=0.02,t=5.424)。脑白质高信号Fazekas分级与MMSE及MoCA评分之间均有统计学差异(P<0.001,χ^(2)=5.639;P<0.001,χ^(2)=5.843),全脑皮层萎缩分级与MMSE评分有统计学差异(P=0.036,χ^(2)=2.895)。结论CSVD认知功能障碍与头颅MR影像学评估分级存在一定相关性。Objective To investigate the correlation between cognitive impairment of cerebral small vessel disease(CSVD)and white matter hyperintensity grade and cerebral atrophy grade.Methods The data of 213 patients with CSVD were analyzed retrospectively.The semi-quantitative Fazekas visual score of brain MR was used to evaluate the white matter hyperintensity,and cerebral atrophy was evaluated by the whole cerebral cortex atrophy grade.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were used to evaluate each patient and to classify according to the results.Results There was a statistically significant difference in age between male and female patients with CSVD(P=0.04,t=4.288).The mean age of males[(66.5±10.3)years]was less than females[(69.5±10.0)years].There was significant difference between patients with different gender and history of hypertension(P=0.02,t=5.424).There were statistical differences between white matter hyperintensity Fazekes grade and MMSE and MoCA scores(P<0.001,χ^(2)=5.639;P<0.001,χ^(2)=5.843),and there were statistical differences between whole cerebral cortex atrophy grade and MMSE score(P=0.036,χ^(2)=2.895).Conclusion There is a certain correlation between cognitive impairment of CSVD and head MR imaging evaluation grade.

关 键 词：脑小血管病 脑白质高信号分级 全脑皮层萎缩分级 认知障碍 

分 类 号：R743[医药卫生—神经病学与精神病学] R742[医药卫生—临床医学]