矿物药南寒水石微区微量元素及氧同位素组成的均一性分析  

Homogeneity Analysis of Trace Elements and Oxygen Isotope Composition in Micro-region of Mineral Medicine Calcitum

作　　者：卓鱼周 ZHUO Yuzhou(Medical Mineral Development Research Center,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学药用矿物研究中心,贵阳550025

出　　处：《中国实验方剂学杂志》2025年第7期163-171,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：贵州省科技计划项目(黔科合基础-ZK[2024]一般348)。

摘　　要：目的:通过矿物原位微区分析方法探究矿物药南寒水石的微量元素及氧同位素组成的均一性问题。方法:收集贵州省贞丰县烂泥沟(LNG-1、LNG-2)、兴仁市太平洞(TPD)和紫木凼(ZMD)、安龙县戈塘(GT),广西壮族自治区田林县高龙(GL)和八渡(BD)、兴仁市凌云县明山(MS)的南寒水石样品。采用X射线能谱面扫描法(EDS)对TPD样品的光薄片进行原位微区的钙(Ca)、锰(Mn)、铁(Fe)元素面扫描分析;采用阴极发光法(CL)对各南寒水石样品的光薄片进行发光性分析;采用激光剥蚀电感耦合等离子体质谱法(LA-ICP-MS)分析LNG-1、TPD、GL、BD样品光薄片的原位微区Mn、Fe、稀土元素的含量及分布均匀性,以及LNG-2、ZMD、GT、MS样品光薄片的原位微区δ^(18)O及分布均匀性。结果:不同产地的南寒水石的元素及氧同位素组成均存在差异性。EDS分析结果显示,南寒水石中的Fe、Mn元素具有明显的环带结构。CL及LA-ICP-MS分析结果显示,南寒水石不同区域阴极光呈红色且明暗不一,其中Mn、Fe及稀土元素的含量为南寒水石阴极光明暗的重要影响因素。Fe元素含量高而Mn元素含量低的区域阴极光颜色较暗,Fe元素含量低而Mn元素含量高的区域阴极光颜色较亮,当稀土元素总含量>10μg·g^(-1)时,将对阴极光的明亮度产生影响,其总含量越高的区域阴极发光颜色也越明亮。在不同产地样品中,MS地区所测试的南寒水石具有最大的δ^(18)O不均一性,且形成了微米级的δ^(18)O差异性环带,同时,阴极光较暗的区域δ^(18)O含量较低,阴极光较亮的区域δ^(18)O含量较高。结论:南寒水石的Fe、Mn、稀土元素及δ^(18)O组成不均一且具有明显的化学成分环带,其中烂泥沟地区的南寒水石因化学成分相对均一,具有较高的Fe、Mn元素含量而具有良好的品质。该研究可为南寒水石质量标准的制定提供实验依据。Objective:To investigate the homogeneity of trace elements and oxygen isotope composition of the calcitum by in situ micro-region analysis.Methods:Samples of calcitum were collected from Lannigou in Zhenfeng county,Guizhou province(LNG-1,LNG-2),Taipingdong(TPD)and Zimudang(ZMD)in Xingren county,Guizhou province,Getang in Anlong county,Guizhou province(GT),Gaolong(GL)and Badu(BD)in Tianlin county,Guangxi province,and Mingshan in Lingyun county,Guangxi province(MS).The surface scanning of Ca,Mn and Fe elements in the microregions of TPD samples was analyzed by X-ray energy spectrum surface scanning method(EDS).Cathodoluminescence method(CL)was used to analyze the luminescence properties of the thin slices of calcitum samples.The content and distribution uniformity of Mn,Fe and rare earth elements in the in situ microregions of LNG-1,TPD,GL and BD samples,and theδ^(18)O and the distribution uniformity in the in situ microregions of the thin slices of LNG-2,ZMD,GT and MS samples were analyzed by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS).Results:The composition of elements and oxygen isotopes of calcitum from different origins were different.EDS analysis results showed that the Fe and Mn elements in calcitum had obvious girdle structure.The results of CL and LA-ICP-MS analysis showed that the cathode light in different regions of calcitum was red and varied in brightness,and the contents of Mn,Fe and rare earth elements were important factors affecting the brightness of the cathode light of calcitum.Regions with high content of Fe and low content of Mn had darker cathode light color,while regions with low content of Fe and high content of Mn had brighter cathode light color.When the total content of rare earth elements was>10μg·g^(-1),the brightness of the cathode light would be affected,and the higher the total content of the region,the brighter the cathode light color would be.Among the samples from different origins,the calcitum tested in MS area had the largestδ^(18)O heterogeneity

关 键 词：南寒水石 微量元素 稀土元素 同位素 成矿流体 中药材 质量均一性 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学] R931[理学—分析化学] O657[理学—化学]