遗传参考种群BXD小鼠在生物医学研究中的应用  

Application of the genetic reference population BXD mice in biomedical research

作　　者：胡兵 宫丽丽 彭亮[1] 张浩军[1] 胡汉昆[2] 刘丽宏 HU Bing;GONG Lili;PENG Liang;ZHANG Haojun;HU Hankun;LIU Lihong(Institute of Clinical Medicine,China-Japan Friendship Hospital,Beijing 100029,China;Department of Pharmacy,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University,Wuhan 430071,Hubei Province,China)

机构地区：[1]中日友好医院临床医学研究所,北京100029 [2]武汉大学中南医院药学部,武汉大学药学院,湖北武汉430071

出　　处：《世界临床药物》2025年第2期188-195,共8页World Clinical Drug

基　　金：2024年武汉大学学位与研究生教育教学改革研究项目(2024YBXM-019)。

摘　　要：BXD重组近交系小鼠系通过将雌性C57BL/6J与雄性DBA/2J小鼠杂交,并经过20代以上的兄弟姐妹交配培育而成,目前已超过150个品系,是世界上规模最大、遗传资料最为完善的哺乳动物重组近交系群体。这些小鼠展现出显著的遗传多样性和广泛的表型多样性,并拥有丰富的基因型、表型及组学数据。这些特性使BXD小鼠成为研究复杂性状和疾病的宝贵资源,可用于疾病模型的构建、疾病机制的研究、药物靶点的发现以及药物的临床前评价。BXD小鼠的应用对于推动生物医学研究的进展、促进疾病的预防和治疗以及实现精准医疗具有重要意义。随着研究的深入,BXD小鼠在更多领域有望发挥更大的作用。The BXD recombinant inbred mouse strains,developed through the hybridization of female C57BL/6J and male DBA/2J mice,followed by over 20 generations of brother-sister matings,represent the largest and most genetically characterized group of recombinant inbred strain populations of mammals globally,with over 150 strains.These mice exhibit significant genetic diversity and extensive phenotypic variation,alongside a wealth of genotype,phenotype,and omics data.These characteristics make BXD mice a valuable resource for studying complex traits and diseases,which can be used for the construction of disease models,the study of disease mechanisms,drug target discovery,and preclinical drug evaluation.The application of BXD mice is crucial in advancing biomedical research,promoting disease prevention and treatment,and achieving precision medicine.With the deepening of research,BXD mice are poised to play a greater role across various fields.

关 键 词：遗传参考群体 BXD重组近交系小鼠 系统遗传学 精准医学 临床前研究 

分 类 号：R-332[医药卫生] R318.0