铜及铜死亡在恶性肿瘤辐射抵抗中的研究现状  

Advances in copper and cuproptosis in radiation resistance of malignant tumors

作　　者：邢中旭 许筱炎 焦旸[2] 周菊英[1] 秦颂兵[1] 王利利[1] Xing Zhongxu;Xu Xiaoyan;Jiao Yang;Zhou Juying;Qin Songbing;Wang Lili(Department of Radiation Oncology,The First Affiliated Hospital of Soochow University,Suzhou 215000,China;School of Radiation Medicine and Protection,Suzhou Medical College of Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学附属第一医院放疗科,苏州215000 [2]苏州大学苏州医学院放射医学与防护学院,苏州215123

出　　处：《中华放射肿瘤学杂志》2025年第3期305-309,共5页Chinese Journal of Radiation Oncology

基　　金：国家自然基金面上项目(82073476);国家重点研发计划(2022YFC2503700,2022YFC 2503703);江苏省医学重点学科(ZDXK202235)。

摘　　要：放射治疗是恶性肿瘤的主要治疗手段之一,辐射抵抗是导致放疗患者复发、进展或远处转移的重要原因,针对辐射抵抗机制及疗法的研究具有重要意义。铜死亡是新发现的一种铜依赖的调节性细胞死亡方式,其机制涉及脂酰化蛋白聚集和Fe-S簇蛋白丢失等。铜以及铜死亡不仅与肿瘤发生发展密切相关,而且参与肿瘤细胞辐射抵抗过程,干预诱导铜死亡有可能改善辐射抵抗。本文对铜及铜死亡与恶性肿瘤细胞辐射抵抗相关的机制和研究现状进行综述,旨在为临床上改善肿瘤细胞辐射抵抗提供参考。Radiotherapy plays a pivotal role in the treatment of malignant tumors.The emergence of radiation resistance in malignant tumors,contributing to tumor recurrence,progression,or distant metastasis,remains a significant treatment challenge.Exploring the mechanisms underlying radiation resistance and overcoming the radio-resistance of tumors have become urgent problems in oncological practice.Cuproptosis,a copper-dependent form of regulated cell death,is driven by the aggregation of lipoylated proteins and the reduction of Fe-S cluster proteins,etc.Copper and cuproptosis are not only intricately related to the incidence and development of tumors,but also participate in radiation resistance of tumor cells.Strategic interventions targeting copper and inducing cuproptosis will present promising avenues for overcoming radiation resistance and further improving the prognosis of tumor patients.This review comprehensively delineates established and potential mechanisms governing the intricate crosstalk between radiation resistance and cuproptosis,aiming to provide reference for overcoming radiation resistance in malignant tumor cells.

关 键 词：肿瘤 放射疗法 铜死亡 辐射耐受性 铜死亡诱导剂 

分 类 号：R73[医药卫生—肿瘤]