维生素D与常见眼部疾病关系的系统综述与荟萃分析  

Systematic review and meta-analysis of the relationship between vitamin D and common ocular diseases

作　　者：何沛原 刘玉萍[1] 帅平[1] 谢雪 HE Pei-yuan;LIU Yu-ping;SHUAI Ping;XIE Xue(Health Management Center(Health Management Research Institute),Sichuan Academy of Medical Sciences/Sichuan Provincial People’s Hospital(Affiliated Hospital of University of Electronic Science and Technology of China),Chengdu,Sichuan 610072,China)

机构地区：[1]四川省医学科学院·四川省人民医院(电子科技大学附属医院),健康管理中心(健康管理研究所),四川成都610072

出　　处：《现代预防医学》2025年第1期180-187,共8页Modern Preventive Medicine

基　　金：四川省科技厅重点研发计划项目(2022YFS0600);院级临床研究及转化基金(2021LY15)。

摘　　要：目的 本研究旨在总结常见眼部疾病患者的维生素D水平,探讨低维生素D水平与眼部疾病发生之间的关系。方法 检索了截至2024年5月25日的Pub Med、Web of Science、Embase和Cochrane数据库,收集荟萃分析研究以评估维生素D与眼部疾病的关系。此外,收集了未包含在现有荟萃分析中的观察性研究,使用随机效应加权均数差(WMD)计算效应值及95%置信区间(CI)。研究结果纳入荟萃分析,最终进行伞状综述。结果 本研究纳入了13项荟萃分析和15项观察性研究(11项病例对照研究和4项横断面研究)。荟萃分析显示,维生素D与眼部疾病研究的综合加权均数差(WMD)=-2.17(95%CI:-2.50--1.84;P=0.282,I2=18.7%)。维生素D在眼部疾病中的总体比值比(OR)=0.96(95%CI:0.92-0.99;P<0.001,I2=87.1%)。并通过试验序贯分析(TSA),验证了本研究结论的稳健性。结论 研究发现较高的维生素D水平与青光眼和近视的发病风险显著降低相关,但与非感染性葡萄膜炎(NIU)的发病风险增加相关。Objective To summarize the levels of vitamin D in patients with common ocular diseases and explore the relationship between low vitamin D levels and the occurrence of ocular diseases.Methods A search was conducted in the PubMed,Web of Science,Embase,and Cochrane databases up to May 25,2024,to collect meta-analysis studies assessing the relationship between vitamin D and ocular diseases.Additionally,observational studies not included in existing meta-analyses were collected,and the effect size and 95%confidence interval(CI)were calculated using the random effects weighted mean difference(WMD).The results of the studies were included in the meta-analysis,culminating in an umbrella review.Results This study included 13 meta-analyses and 15 observational studies(11 case-control studies and 4 cross-sectional studies).The meta-analysis indicated that the overall weighted mean difference(WMD)for vitamin D and ocular diseases was-2.17(95%CI:-2.50 to-1.84;P=0.282,I2=18.7%).The overall odds ratio(OR)for vitamin D in ocular diseases was 0.96(95%CI:0.92 to 0.99;P<0.001,I2=87.1%).The robustness of the conclusions was verified through trial sequential analysis(TSA).Conclusion Higher vitamin D levels are significantly associated with a reduced risk of developing glaucoma and myopia,yet showing an association with an increased risk of non-infectious uveitis(NIU).

关 键 词：维生素D 眼部疾病 伞状综述 荟萃分析 观察性研究 

分 类 号：R771[医药卫生—眼科]