丙戊酸钠联合氯氮平治疗男性难治性精神分裂症伴激越行为的临床疗效  

Clinical Efficacy of Sodium Valproate combined with Clozapine in the Treatment of Male Refractory Schizophrenia with Agitation Behavior

作　　者：陈磊 余万庆 胡承国 CHEN Lei;YU Wanqing;HU Chengguo(Department of Psychiatry,Affiliated Hospital of West Anhui Health Vocational College(Lu'an Second People's Hospital),Lu'an 237000,China)

机构地区：[1]皖西卫生职业学院附属医院(六安市第二人民医院)精神科,六安237000

出　　处：《国际精神病学杂志》2025年第1期47-49,61,共4页Journal Of International Psychiatry

基　　金：安徽高校自然科学研究项目(KJ2021A1370)。

摘　　要：目的 探讨丙戊酸钠联合氯氮平治疗男性难治性精神分裂症(treatment resistant schizophrenia,TRS)伴激越行为的临床疗效。方法 将2022年3月~2024年3月80例男性TRS伴激越行为患者按数字表随机法分成两组。对照组采用氯氮平治疗,观察组联合丙戊酸钠治疗。比较治疗前后精神症状、激越行为以及用药期间不良反应。结果 治疗后两组患者一般精神病理、阳性、阴性症状评分均下降,但观察组各项评分均低于对照组(P<0.05);治疗后两组激越行为评分均下降,但观察组评分低于对照组(P<0.05);两组治疗2、4、8周时副反应量表(Treatment emergent symptom scale,TESS)评分差异无统计学意义(P>0.05)。结论 丙戊酸钠联合氯氮平治疗男性TRS患者能够提升近期临床疗效,并减轻激越行为,不增加不良反应。Objective To explore the clinical efficacy of sodium valproate combined with clozapine in the treatment of male refractory schizophrenia(TRS)with agitation behavior.Methods Eighty male patients with TRS and agitation behavior from March 2022 to March 2024 were divided into two groups using the random number table method.The control group was treated with clozapine,while the observation group was treated with a combination of sodium valproate.The mental symptoms,agitation behavior,and adverse reactions during medication before and after treatment were compared.Results After treatment,the general psychopathology,positive and negative symptom scores of both groups of patients decreased,but the observation group had lower scores than the control group in all aspects(P<0.05).After treatment,both groups showed a decrease in agitated behavior score,but the observation group had lower scores than the control group(P<0.05).There was no statistically significant difference in the Treatment Emergency Symptom Scale(TESS)scores between the two groups at 2,4,and 8 weeks of treatment(P>0.05).Conclusion The combination of sodium valproate and clozapine in the treatment of male TRS patients can improve short-term clinical efficacy,reduce agitation behavior,and not increase adverse reactions.

关 键 词：丙戊酸钠 氯氮平 男性 难治性精神分裂症 激越行为 

分 类 号：R749.053[医药卫生—神经病学与精神病学]