稳定期精神分裂症患者QTc间期延长发生情况及风险因素  

Occurrence and risk factors of QTc interval prolongation in patients with stable schizophrenia

作　　者：郭蕊 成杰[1] 李霞 韩勇[1] GUO Rui;CHENG Jie;LI Xia(The Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453002,China)

机构地区：[1]新乡医学院第二附属医院,新乡453002 [2]新乡第二人民医院

出　　处：《国际精神病学杂志》2025年第1期65-67,105,共4页Journal Of International Psychiatry

基　　金：河南省科技发展计划(编号:232102311031)。

摘　　要：目的探讨精神分裂症(schizophrenia,SZ)稳定期患者QTc间期延长发生情况及临床危险因素。方法选择2022年6月~2023年10月154例SZ稳定期患者,观察住院用药期间是否发生QTc间期延长,采用单因素分析比较有、无QTc间期延长患者一般资料、用药情况等,多因素分析调查QTc间期延长的影响因素。结果154例SZ稳定期患者中有34例患者而出现QTc间期延长,发生率22.08%;有、无QTc间期延长患者年龄、性别、病程、吸烟、体质指数、合并代谢综合征、用药情况、血钾浓度差异具有统计学意义(P<0.05);两组血钙浓度、饮酒史、SZ家族史差异不显著(P>0.05);多因素分析显示,年龄、合并代谢综合征、血钾浓度、女性、联合用药是SZ稳定期QTc间期延长的影响因素。结论SZ稳定期QTc间期延长发生率较高,年龄大、合并代谢综合征、血钾浓度低会增加QTc间期延长发生风险。Objective To investigate the occurrence of QTc interval prolongation and clinical risk factors in patients stable schizophrenia(SZ).Methods A total of 154 patients with stable SZ were selected from June 2022 to October 2023 to observe whether QTc interval prolongation occurred during hospitalization for medication.Univariate analysis was used to compare the general information and medication use of patients with and without QTc interval prolongation.Multifactorial analysis was used to investigate the influencing factors of QTc interval prolongation.Results 34 cases with stable SZ had QTc interval prolongation,with an incidence rate of 22.08%.The differences in age,gender,disease duration,smoking,body mass index,comorbid metabolic syndrome,medication use,and blood potassium concentration between patients with and without QTc interval prolongation were statistically significant(P<0.05).The differences in blood calcium concentration,history of alcohol consumption,and family history of SZ between the two groups were not significant(P>0.05).Multifactorial analysis showed that age,comorbid metabolic syndrome,blood potassium concentration,female,and co-medication were the influencing factors for prolongation of QTc interval in stable SZ.Conclusion The incidence of QTc interval prolongation is higher during the stable phase of SZ,and older age,comorbid metabolic syndrome,and low blood potassium concentrations increase the risk of QTc interval prolongation.

关 键 词：精神分裂症稳定期 QTC间期延长 发生情况 危险因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]