不同剂量氯化琥珀胆碱复合丙泊酚用于无抽搐电休克治疗患者对谵妄风险及应激反应的影响  

Effects of different doses of succincholine chloride combined with propofol on delirium risk and stress response in patients treated with electroconvulsive therapy without convulsions

作　　者：张列 朱伟波 陈运昭 魏国辉 ZHANG Lie;ZHU Weibo;CHEN Yunzhao(HE BEI SHENG DI SAN RONG JUN YOU FU YI YUAN,Baoding 071000,China)

机构地区：[1]河北省第三荣军优抚医院,保定071000 [2]博野县医院

出　　处：《国际精神病学杂志》2025年第1期75-78,共4页Journal Of International Psychiatry

基　　金：河北省医学科学研究课题计划(编号:201917441)。

摘　　要：目的 探讨不同剂量氯化琥珀胆碱复合丙泊酚用于无抽搐电休克治疗(Modified Electroconvulsive Therapy,MECT)患者对谵妄风险及应激反应的影响。方法 选取2021年1月至2023年10月于本院行无抽搐电休克治疗患者300例,采取随机数表法分为观察组和对照组,各150例。对照组给予氯化琥珀胆碱复合丙泊酚0.5 mg/kg进行麻醉,观察组给予1.0 mg/kg氯化琥珀胆碱复合丙泊酚。比较两组患者应激反应因子指标[肾上腺素(Epinephrine,E)、去甲肾上腺素(Norepinephrine,NE)、皮质醇(Cortisol,Cor)],另外比较其谵妄发生例数、发作时间及类型。结果 观察组麻醉后E、NE、Cor指标低于对照组,差异有统计学意义(P<0.05);观察组谵妄总发生率10.67%、兴奋型谵妄占比37.50%低于对照组19.33%、72.41%,差异有统计学意义(P<0.05)。结论 1.0 mg/kg氯化琥珀胆碱复合丙泊酚用于MECT可降低谵妄风险,减轻应激反应。Objective To investigate the effects of different doses of succincholine chloride combined with propofol on delirium risk and stress response in patients treated with Modified Electroconvulsive Therapy(MECT).Methods 300 patients who underwent non convulsive electroconvulsive therapy in our hospital from January 2021 to October 2023 were selected and randomly divided into an observation group and a control group,with 150 cases in each group,using a random number table method.The control group was given succincholine chloride(0.5 mg/kg)combined with propofol for anesthesia,and the observation group was given 1.0 mg/kg succincholine chloride combined with propofol.Compare the stress response factor indicators[epinephrine(E),norepinephrine(NE),and cortisol(Cor)]between two groups of patients,and also compare the number,duration,and type of delirium occurrence.Results The E,NE,and Cor indicators in the observation group were lower than those in the control group after anesthesia,and the difference was statistically significant(P<0.05).The total incidence of delirium in the observation group was 10.67%,and the proportion of excitatory delirium was 37.50%,which was lower than that in the control group(19.33%,72.41%),and the difference was statistically significant(P<0.05).Conclusion 1.0 mg/kg succincholine chloride combined with propofol in MECT can reduce the risk of delirium and alleviate stress response.

关 键 词：氯化琥珀胆碱 丙泊酚 无抽搐电休克 应激反应 谵妄 

分 类 号：R749.054[医药卫生—神经病学与精神病学]