正念认知治疗对首发抑郁障碍患者的疗效、服药依从性、复发率、再住院率的影响  

Efficacy of Mindfulness Based Cognitive Therapy on efficacy,medication adherence,recurrence rate,and rehospitalization rate in patients with depressive disorder

作　　者：段登艾 张勇辉[1] 王维[1] 廖欣菊 韦海龙 DUAN Deng’ai;ZHANG Yonghui;WANG Wei(Yunnan Provincial Psychiatric Hospital,Kunming 650224,China)

机构地区：[1]云南省精神病医院,昆明650224

出　　处：《国际精神病学杂志》2025年第1期102-105,共4页Journal Of International Psychiatry

基　　金：云南省教育厅科学研究基金项目(编号:2024J0315);昆明市卫生科技人才培养项目(编号:2023-SW(后备)-06)。

摘　　要：目的 探索正念认知治疗(Mindfulness Based Cognitive Therapy,MBCT)对抑郁障碍患者的疗效、服药依从性、复发率、再住院率的影响。方法 纳入我院住院的首发抑郁障碍患者68例,按1:1的比例随机分至对照组(口服阿戈美拉汀片)及联合组(在口服阿戈美拉汀片基础上,合并团体MBCT),观察2组患者8周后汉密尔顿抑郁量表(Hamilton Depression scale,HAMD)的减分情况,以及干预后的6月、12月的服药依从性、复发率、再住院率。结果 联合组HAMD的减分情况更明显(z=-2.309,P<0.05);干预后6月2组服药依从性、复发率、再住院率无差异,12月时联合组的服药依从性更高、复发率更低、再住院率更低。结论 MBCT能够显著缓解首发抑郁障碍患者的抑郁症状;能提高服药依从性,降低复发率及再住院率,远期效果更佳。Objective To explore the impact of Mindfulness Based Cognitive Therapy on the efficacy,medication adherence,recurrence rate,and rehospitalization rate in patients with depressive disorder.Methods A total of 68 first-episode depressive disorder inpatients were included and randomly assigned in a 1:1 ratio to the control group(oral agomelatine)or the combination group(oral agomelatine plus group-based MBCT).We assessed the Hamilton Depression scale,medication adherence,relapse rate,rehospitalization rate within 6 and 12 months after the intervention.Results The score of HAMD was reduce more obvious in the combination group(z=-2.309,P<0.05).There was no difference in medication adherence,relapse rate,and rehospitalization rate in the 2 groups after 6 months intervention,and higher medication adherence,lower relapse rate,and lower rehospitalization rate in the combination group at December.Conclusions The MBCT was able to significantly relieve depressive symptoms in patients with depressive disorders.It can improve medication compliance,reduce the recurrence rate and rehospitalization rate,and increase the long-term effect.

关 键 词：正念认知治疗 抑郁障碍 服药依从性 复发率 再住院率 

分 类 号：R749.05[医药卫生—神经病学与精神病学]