阿戈美拉汀治疗抑郁症疗效及对CPC睡眠参数的影响  

Efficacy of agomelatine in the treatment of depression and its effect on CPC sleep parameters

作　　者：李阿云 文晓丽 李丽娜 欧阳山丹 LI Ayun;WEN Xiaoli;LI Lina(Pharmacy Department of the 73rd Group Army Hospital of the People's Liberation Army of China,Xiamen 361003,China)

机构地区：[1]中国人民解放军陆军第七十三集团军医院药剂科,厦门361003

出　　处：《国际精神病学杂志》2025年第1期114-116,185,共4页Journal Of International Psychiatry

基　　金：福建省自然科学基金资助项目(编号:2021J01875)。

摘　　要：目的 探讨阿戈美拉汀治疗抑郁症疗效及对心肺耦合(cardio pulmonary coupling,CPC)睡眠参数的影响。方法 将2021年1月~2023年8月100例抑郁症按数字表法随机分组,对照组48例运用舍曲林,观察组52例运用阿戈美拉汀。比较情绪评分、CPC睡眠参数、副反应量表(treatment emergent symptom scale,TESS)。结果 治疗前后相比两组汉密尔顿抑郁量表17项、汉密尔顿焦虑量表均显著降低(P<0.05),治疗后组间差异不显著(P>0.05);治疗前后相比两组总睡眠、熟睡时间、睡眠品质评分增加,入睡、浅睡、低通气指数降低(P<0.05),并且治疗后观察组各参数均优于对照组(P<0.05);两组治疗2、4、8周时TESS评分差异不显著(P>0.05)。结论 阿戈美拉汀治疗抑郁症与舍曲林能获得一致的临床疗效且安全性相当,但前者能够有效改善CPC睡眠参数,提升睡眠质量。Objective To investigate the efficacy of agomelatine in the treatment of depression and its effect on cardio pulmonary coupling(CPC)sleep parameters.Methods A total of 100 cases of depression from January 2021 to August 2023 were randomized according to the numerical table method,48 cases in the control group applied sertraline and 52 cases in the observation group applied agomelatine.Mood scores,CPC sleep parameters,and treatment emergent symptom scale(TESS)were compared.Results Hamilton depression scale-17 and Hamilton anxiety scale were significantly reduced in both groups after treatment(P<0.05).The difference between the groups after treatment was not significant(P>0.05).Total sleep,time asleep,sleep quality scores increased,and falling asleep,light sleep,and hypoventilation index decreased in both groups after treatment(P<0.05).And all parameters of the observation group were better than the control group after treatment(P<0.05).The difference in TESS scores between the two groups at 2,4 and 8 weeks of treatment was not significant(P>0.05).Conclusion Agomelatine for depression and sertraline achieved consistent clinical efficacy and comparable safety,but the former was effective in improving CPC sleep parameters and enhancing sleep quality.

关 键 词：阿戈美拉汀 舍曲林 抑郁症 心肺耦合睡眠参数 

分 类 号：R749.05[医药卫生—神经病学与精神病学]