喹硫平及认知行为干预对双相情感障碍患者的效果  

The intervention value of quetiapine and cognitive-behavioral intervention in patients with bipolar disorder

作　　者：张煌辉 张园 ZHANG Huanghui;ZHANG Yuan(Department of Psychiatry,Xiamen Xianyue Hospital,Xianyue Hospital Affilia ted with Xiamen Medical College,Fujian Psychiatric Center,Fujian Clinical Research Center for Mental Disorders,Xiamen 361000,China)

机构地区：[1]厦门市仙岳医院,厦门医学院附属仙岳医院,福建省精神医学中心,福建省精神疾病临床医学研究中心精神科,厦门361000

出　　处：《国际精神病学杂志》2025年第1期128-131,共4页Journal Of International Psychiatry

基　　金：厦门市科技计划项目(编号:3502Z202374099)。

摘　　要：目的 探讨喹硫平及认知行为干预对双相情感障碍(Bipolar Disorder,BPD)患者的干预价值。方法 纳入BPD住院患者100例,纳入时间2021年1月~2024年5月,按随机数表方式分观察、对照组,均50例。两组均予以常规干预,对照组(喹硫平),观察组(喹硫平+认知行为干预)。比较两组杨氏躁狂评定量表(Young Mania Rating Scale,YMRS)、(Self-rating depression scale,SDS)评分,另外评估其蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)、简易应对方式问卷(Simplified Coping Style Questionnaire,SCSQ)评分。结果 干预后较干预前,两组YMRS、SDS评分均降低,且观察组均低于对照组(P<0.05);干预后较干预前,两组MoCA、SCSQ积极应对评分均升高,SCSQ消极应对评分则降低,且观察组较对照组,MoCA、SCSQ积极应对评分均更高,SCSQ消极应对评分均更低(P<0.05)。结论 喹硫平及认知行为干预用于BPD可改善患者抑郁、躁狂症状、认知功能及应对疾病方式。Objective To explore the intervention value of quetiapine and cognitive-behavioral intervention in patients with bipolar disorder(BPD).Methods 100 hospitalized patients with BPD were included from January 2021 to May 2024.They were randomly divided into an observation group and a control group,with 50 cases in each group.Both groups received routine intervention,the control group(quetiapine)and the observation group(quetiapine+cognitivebehavioral intervention).Compare the scores of two groups of Young Mania Rating Scale(YMRS)and Self rating Depression Scale(SDS),and evaluate their scores on the Montreal Cognitive Assessment(MoCA)and Simplified Coping Style Questionnaire(SCSQ).Results After the intervention,the YMRS and SDS scores of both groups decreased compared to before the intervention,and the observation group was lower than the control group(P<0.05).After intervention,compared with before intervention,both groups showed an increase in MoCA and SCSQ positive coping scores,while SCSQ negative coping scores decreased.Moreover,the observation group had higher MoCA and SCSQ positive coping scores and lower SCSQ negative coping scores than the control group(P<0.05).Conclusion Quetiapine and cognitive-behavioral interventions can improve depression,manic symptoms,cognitive function,and coping strategies in patients with BPD.

关 键 词：喹硫平 认知行为干预 双相情感障碍 认知功能 应对疾病方式 

分 类 号：R749.05[医药卫生—神经病学与精神病学]