乳酸链球菌素对肉兔生长性能、养分消化、免疫性能和抗氧化能力的影响  

Effects of Nisin on Growth Performance,Nutrient Digestion,Immunity and Antioxidant Capacity of Meat Rabbits

作　　者：范慧敏 贾子凡 韩雯笑 赵桂春 陈宝江[1] 田建兴 谷子林[1] 陈赛娟[1,2] FAN Huimin;JIA Zifan;HAN Wenxiao;ZHAO Guichun;CHEN Baojiang;TIAN Jianxing;GU Zilin;CHEN Saijuan(College of Animal Science and Technology,Hebei Agricultural University,Baoding 071001,China;Agricultural Technology Innovation Centre in Mountainous Areas of Hebei Province,Baoding 071001,China;Haixing County Agriculture and Rural Bureau,Cangzhou 061299,China;Liaoning Weilan Biotechnology Co.,Ltd.,Shenyang 110034,China;Worui Biotechnology(Shanghai)Co.,Ltd.,Shanghai 201799,China)

机构地区：[1]河北农业大学动物科技学院,保定071001 [2]河北省山区农业技术创新中心,保定071001 [3]海兴县农业农村局,沧州061299 [4]辽宁威兰生物技术有限公司,沈阳110034 [5]渥瑞生物科技(上海)有限公司,上海201799

出　　处：《动物营养学报》2025年第3期1963-1971,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：河北省自然科学基金项目(C2023204298);河北省特色养殖产业技术体系创新团队(HBCT2024280204);国家兔产业技术体系(CARS-43-B-2)。

摘　　要：本试验旨在研究乳酸链球菌素(Nisin)对肉兔生长性能、养分消化、免疫性能和抗氧化能力的影响,为肉兔生产中合理使用Nisin提供理论依据。选取35日龄体重[(957.12±71.42)g]相近的伊拉商品代肉兔144只,随机分为4组,每组6个重复,每个重复6只(公母各占1/2)。对照组肉兔饲喂基础饲粮,试验1、2、3组肉兔分别饲喂在基础饲粮中添加200、350、500 g/t Nisin的试验饲粮。试验期为35 d,第1~7天为预备试验期,第8~35天为正式试验期。结果显示:1)与对照组相比,所有试验组肉兔的终末体重(FBW)和平均日增重(ADG)均显著提高(P<0.05),且随着Nisin添加量的增加,FBW和ADG呈线性和二次变化(P<0.05)。与对照组相比,饲粮中添加350和500 g/t Nisin可显著降低肉兔的料重比(F/G),且随着Nisin添加量的增加,F/G呈线性和二次变化(P<0.05)。试验2、3组肉兔均未出现死亡。2)与对照组相比,添加350和500 g/t Nisin能够提高肉兔对粗脂肪的表观消化率(P<0.05),且其随着Nisin添加量的增加呈线性变化(P<0.05)。与对照组相比,饲粮中添加500 g/t Nisin能够提高肉兔对粗蛋白质、粗纤维、粗灰分的表观消化率(P<0.05),肉兔对粗灰分的表观消化率随着Nisin添加量的增加呈线性和二次变化(P<0.05),粗蛋白质的表观消化率呈线性变化(P<0.05)。与对照组相比,所有试验组肉兔对酸性洗涤纤维的表观消化率均显著提高(P<0.05)。3)与对照组相比,试验3组肉兔空肠食糜中脂肪酶活性显著增加(P<0.05),试验1、2、3组肉兔空肠食糜中胰蛋白酶活性显著升高(P<0.05),且随着Nisin添加量的增加,空肠食糜中脂肪酶和胰蛋白酶活性呈线性和二次变化(P<0.05)。饲粮中添加Nisin对肉兔胃内容物中胃蛋白酶和空肠食糜中α-淀粉酶活性无显著影响(P>0.05)。4)与对照组相比,饲粮中添加200和500 g/t Nisin能够显著降低肉兔血清中白细胞介素-6的含量(P<0.05)。5)与对照组相比,饲粮中This experiment was conducted to investigate the effects of Nisin on growth performance,nutrient digestion,immunity and antioxidant capacity of meat rabbits,and to provide theoretical basis for rational use of Nisin in meat rabbit production.A total of 144 Ila commercial meat rabbits at 35 days of age with similar body weight[(957.12±71.42)g]were randomly divided into 4 groups with 6 replicates per group and 6 rabbits(half male and half female)per replicate.Rabbits in the control group were fed a basal diet,and rabbits in test groups 1,2 and 3 were fed the basal diet supplemented with 200,350 and 500 g/t Nisin,respectively.The experiment lasted for 35 days,with days 1 to 7 as pre-feeding period and days 8 to 35 as formal experiment period.The results were as follows:1)compared with the control group,final body weight(FBW)and average daily gain(ADG)were significantly increased in all experimental groups(P<0.05),and with the increase of Nisin supplemental level,FBW and ADG showed linear and quadratic changes(P<0.05).Compared with the control group,dietary supplementation of 350 and 500 g/t Nisin significantly decreased the feed/gain ratio(F/G)(P<0.05),and with the increase of dietary Nisin supplemental level,F/G had linear and quadratic changes(P<0.05).There was no death of meat rabbits in test groups 2 and 3.2)Compared with the control group,dietary supplementation of 350 and 500 g/t Nisin significantly increased the apparent digestibility of ether extract of meat rabbits(P<0.05),and it showed a linear change with the increase of Nisin supplemental level(P<0.05).Compared with the control group,dietary supplementation of 500 g/t Nisin significantly increased the apparent digestibility of crude protein,crude fibre and crude ash of meat rabbits,and the apparent digestibility of crude ash showed linear and quadratic changes with the increase of Nisin supplemental level(P<0.05).Compared with the control group,the apparent digestibility of acid detergent fiber of meat rabbits in all experimental groups was significantl

关 键 词：乳酸链球菌素 肉兔 生长性能 养分消化 免疫性能 抗氧化能力 

分 类 号：S829.1[农业科学—畜牧学]