GRIM19在不同疾病中的作用  

The Role of GRIM19 in Different Diseases

作　　者：李宇豪 张佳臣 王昊 白英[1] LI Yuhao;ZHANG Jiachen;WANG Hao;BAI Ying(Cardiovascular Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Beijing Diabetes Institute,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院心血管病中心,中国北京100730 [2]首都医科大学附属北京同仁医院北京市糖尿病研究所,中国北京100730

出　　处：《生命科学研究》2025年第1期32-40,48,共10页Life Science Research

基　　金：北京市自然科学基金项目(7232232);北京市属医院科研培育计划项目(PX2023006);2023年本科生科研训练项目(XSKY2023)。

摘　　要：GRIM19蛋白是线粒体氧化呼吸链还原型烟酰胺腺嘌呤二核苷酸(reduced nicotinamide adenine dinucleotide,NADH)脱氢酶复合物Ⅰ的亚基,是线粒体维持结构和功能完整性不可或缺的组成部分。最初,GRIM19被认为是一种新型肿瘤抑制基因,主要在肿瘤增殖和凋亡中发挥重要作用。近年来,GRIM19在其他疾病中的作用不断受到关注,如自身免疫性疾病、心血管疾病、感染性疾病、肥胖、糖尿病、子宫腺肌病、弱精子症和流产等。本文介绍了GRIM19蛋白在细胞正常生理过程中的功能,回顾了其在不同疾病中的作用,为相关疾病的防治提供了新的策略,并为该领域的后续研究提供了一定的参考。The GRIM19 protein is a subunit of the mitochondrial respiratory chain-linked reduced nicotinamide adenine dinucleotide(NADH)dehydrogenase complex玉.It is integral to the maintenance of structural and functional integrity of mitochondria.Initially,GRIM19 was considered to be a novel tumor suppressor gene that plays an important role mainly in tumor proliferation and apoptosis.In recent years,the role of GRIM19 in other diseases,such as autoimmune diseases,cardiovascular diseases,infectious diseases,obesity,diabetes mellitus,adenomyosis,asthenospermia and miscarriage,has received increasing attention.This review introduces the functions of the GRIM19 protein in normal cellular physiological processes,summarizes its role in different diseases.The paper may provide new strategies for the prevention and treatment of related diseases,and some references for subsequent research in this field.

关 键 词：GRIM19蛋白 癌症 代谢性疾病 心血管疾病 免疫性疾病 生殖系统疾病 

分 类 号：Q71[生物学—分子生物学] R363[医药卫生—病理学]