Consideration of liquid biomarkers for surveillance of HPV-related oropharyngeal cancer in veteran populations  

作　　者：Joshua D.Smith Matthew E.Spector J.Chad Brenner Jessica H.Maxwell 

机构地区：[1]Department of Otolaryngology-Head&Neck Surgery,University of Michigan,Ann Arbor,MI 48109,USA [2]Department of Otolaryngology-Head&Neck Surgery,University of Pittsburgh Medical Center,Pittsburgh,PA 15213,USA [3]Rogel Cancer Center,University of Michigan,Ann Arbor,MI 48109,USA [4]Section of Otolaryngology,Pittsburgh Veterans Affairs Medical Center,Pittsburgh,PA 15240,USA

出　　处：《Journal of Cancer Metastasis and Treatment》2024年第1期255-265,共11页癌症转移与治疗(英文版)

基　　金：supported by a 2022 AHNS CORE Grant Presidential Award.

摘　　要：The incidence of human papillomavirus(HPV)-related oropharyngeal squamous cell carcinoma(OPSCC)will continue to rise in the United States over the next several decades.Thus,efforts to reduce treatment intensity,mitigate long-term physical and psychological sequelae of treatment,and simplify surveillance regimens for patients with HPV-related OPSCC are critical.Liquid biomarkers,namely plasma circulating tumor HPV DNA(ctDNA),have shown considerable promise for improvements in these domains by guiding personalized and adaptive treatment de-escalation paradigms and predicting disease recurrence in the survivorship period.Preliminary reports suggest an even broader impact of plasma HPV ctDNA assays for HPV-related OPSCC surveillance beyond the mere detection of cancer recurrence and metastasis.For instance,such assays may reduce the need for costly imaging studies,alleviate the financial toxicities of survivorship care,and improve care access and patient satisfaction.Currently,veterans and underserved populations are disproportionately affected by the financial burden of cancer surveillance and survivorship care.These disparities negatively impact oncologic outcomes,healthcare access,and utilization,specifically among veterans with HPV-related OPSCC.As such,we posit that HPV ctDNA monitoring may be of unique benefit and impact in the surveillance period for these patients specifically.Herein,we provide a narrative review of the current literature supporting the formal clinical evaluation of HPV ctDNA monitoring in veterans with HPV-related OPSCC.

关 键 词：HPV ctDNA liquid biomarker OROPHARYNX squamous cell carcinoma SURVEILLANCE VETERANS 

分 类 号：R73[医药卫生—肿瘤]