Copper-catalyzed regioselective acyloxy-trifluoromethylation of allenamides with togni'sⅡreagent  

铜催化联烯胺与Togni'sⅡ试剂的区域选择性三氟甲基化酯化反应

作　　者：TONG Xiang-yan CHENG Song ZHAO Qi LUO Cheng-xiang PENG Lin-Jie LI Xiao-xiao ZHAO Zhi-gang 佟香妍;成松;赵祺;罗呈翔;彭林杰;李肖肖;赵志刚(西南民族大学化学与环境学院,四川成都610041)

机构地区：[1]College of Chemistry and Environment,Southwest Minzu University,Chengdu 610041,China

出　　处：《化学研究与应用》2025年第3期631-643,共13页Chemical Research and Application

基　　金：西南民族大学大学生创新训练项目(202410656048)资助。

摘　　要：An efficient copper-catalyzed regioselective acyloxy-trifluoromethylation of allenamides using Togni'sⅡreagent as the source of both the trifluoromethyl and acyloxy moieties was developed to create a workable route to CF_(3)-substituted allylic esters.The reaction exhibited good functional group tolerance and high efficiency,affording the products in moderate to good yields.Mechanistic investigations indicated a radical process was likely involved in this transformation.本文报道了一种通过铜催化联烯胺与Togni'sⅡ试剂的区域选择性三氟甲基化酯化反应合成三氟甲基取代的烯丙基酯衍生物的方法。在该反应中,Togni'sⅡ试剂同时作为三氟甲基源和酯基源。该方法底物普适性好,效率高,以较好的产率得到一系列三氟甲基化的烯丙基酯产物,机理验证实验证明该反应可能是通过自由基过程实现的。

关 键 词：ALLENAMIDES Togni's reagent acyloxy-trifluoromethylation COPPER-CATALYZED 

分 类 号：O631.5[理学—高分子化学]