基于磁化转移成像技术在特发性震颤与帕金森病鉴别诊断中的价值探究  

The Value of Magnetization Transfer Imaging in the Differential Diagnosis of Essential Tremor and Parkinson's Disease

作　　者：董林菘 陈绍华 石玥 杜禹辛 李洪义 魏秀芳 DONG Linsong;CHEN Shaohua;SHI Yue(Mudanjiang Medical University,Mudanjiang,Helongjiang Province 157011,P.R.China)

机构地区：[1]牡丹江医科大学,157011 [2]牡丹江医科大学附属红旗医院

出　　处：《临床放射学杂志》2025年第4期586-590,共5页Journal of Clinical Radiology

基　　金：黑龙江省重点研发计划项目(编号:2024ZX12C35);黑龙江省属高等学校基本科研业务费科研项目(编号:2023-KYYWFMY-0014);黑龙江省卫生健康委科技计划项目(编号:2022090910679)。

摘　　要：目的应用磁化转移成像(MTI)技术探究其在特发性震颤(ET)与帕金森病(PD)鉴别诊断中的价值。方法搜集ET和PD患者各39例的MTI数据,以双侧黑质内侧、黑质外侧、蓝斑、丘脑腹侧、额叶、小脑皮质区为感兴趣区域进行勾画并测定其磁化转移率值(MTR),并对测定数据进行统计学分析并绘制有统计学意义的测量区域受试者工作特征(ROC)曲线。结果在测定的感兴趣区域中,丘脑腹侧(右侧)、双侧额叶、蓝斑区域的MTR值差异无统计学意义(P>0.05),在丘脑腹侧(左侧)区域的MTR值差异具有统计学意义(P<0.05),在黑质、小脑皮质区域的MTR值差异具有统计学意义(P<0.001),在双侧黑质、小脑区域取得了较好的ROC曲线与曲线下面积(AUC>0.7)并得出相应的最佳阈值、敏感度与特异度。结论MTI技术能够为ET与PD提供鉴别诊断依据,在区分ET与PD患者中具有较好的参考价值,为ET与PD的病理生理机制的了解提供一定的帮助。Objective To explore the value of magnetic transfer imaging technology in the differential diagnosis of Essential tremor(ET)and Parkinson's disease(PD).Methods Magnetization transfer imaging(MTI)data were collected from 39 patients with essential tremor and 39 patients with Parkinson's disease.The regions of interest(ROI)were delineated and the magnetization transfer rates(MTR)were measured in the bilateral medial and lateral substantia nigra,locus coeruleus,ventral thalamus,frontal lobe,and cerebellar cortex.Statistical analysis was performed on the measured data,and the receiver operating characteristic(ROC)curve was plotted for the statistically significant measurement areas.Results In the measured regions of interest,the MTR values in the ventral thalamus(right side),bilateral frontal lobes,and locus coeruleus were not statistically significant(P>0.05),while the MTR values in the ventral thalamus(left side)region were statistically significant(P<0.05).The MTR values in the substantia nigra and cerebellar cortex regions were statistically significant(P<0.001),and good receiver operating characteristic(ROC)and area under the curve(AUC>0.7)were achieved in the bilateral substantia nigra and cerebellar regions,and the corresponding optimal thresholds,sensitivity,and specificity were obtained.Conclusion Magnetization transfer imaging technology can provide a differential diagnostic basis for essential tremor and Parkinson's disease,and has good reference value in distinguishing essential tremor patients from Parkinson's disease patients.It provides certain help for understanding the pathophysiological mechanisms of ET and PD.

关 键 词：磁共振磁化转移率成像技术 特发性震颤 帕金森病 鉴别诊断 

分 类 号：R74[医药卫生—神经病学与精神病学]