SMARCA4缺失型非小细胞肺癌的SPP1表达及其与PD-L1的关系  

SPP1 expression in SMARCA4-deficient non-small cell lung cancer and its relationship with PD-L1

作　　者：吴娟[1] 黄曦 李佳嘉 魏雨晴 张丽琴 俞咏梅 陆志伟 张鹤 WU Juan;HUANG Xi;LI Jiajia;WEI Yuqing;ZHANG Liqing;YU Yongmei;LU Zhiwei;ZHANG He(Department of Pathophysiology,Wannan Medical College,Yijishan Hospital,Wannan Medical College,Wuhu 241002,Anhui,China;Department of Pathology,Yijishan Hospital,Wannan Medical College,Yijishan Hospital,Wannan Medical College,Wuhu 241002,Anhui,China;Department of Respiratory and Critical Medcine,Yijishan Hospital,Wannan Medical College,Yijishan Hospital,Wannan Medical College,Wuhu 241002,Anhui,China;Department of Medical Imaging Center,Yijishan Hospital,Wannan Medical College,Wuhu 241002,Anhui,China)

机构地区：[1]皖南医学院病理生理学教研室,安徽芜湖241000 [2]皖南医学院第一附属医院弋矶山医院病理科,安徽芜湖241000 [3]皖南医学院第一附属医院弋矶医院呼吸与危重症医学科,安徽芜湖241000 [4]皖南医学院第一附属医院弋矶山医院影像中心,安徽芜湖241000

出　　处：《中国临床药理学与治疗学》2025年第4期477-486,共10页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：2024年度安徽省高校科研项目(2024AH051949);2022年皖南医学院自然科学研究重点项目(WK2022Z11);2021年安徽省教育厅重大项目(KJ2021ZD0105)。

摘　　要：目的:分析SMARCA4缺失型非小细胞肺癌中分泌性磷蛋白1(SPP1)及细胞程序性死亡-配体1(PD-L1)的表达,为罕见病理类型肺癌后续治疗研究提供科学依据。方法:回顾性分析12例SMARCA4缺失型非小细胞肺癌患者的临床与病理特征,根据其形态学分为腺癌与低分化癌两组,分析SPP1与PD-L1在两组的表达与关系。结果:所有患者均检出SPP1表达且其在低分化癌组表达水平较腺癌组显著升高(P=0.015);PD-L1表达者占6/7(5例未测),较之腺癌组,PD-L1亦在低分化癌组高表达(P=0.048),两组的PD-L1表达差异与SPP1表达差异一致。结论:SMARCA4缺失型非小细胞肺癌具有较高的SPP1及PD-L1阳性表达,病理形态为低分化癌者更甚,SPP1与PD-L1在SMARCA4缺失型非小细胞肺癌中的表达情况可能具有正相关性,其关联机制及免疫治疗中作用有待后续研究进一步探讨。AIM:To analyze the expression of secreted phosphoprotein 1(SPP1)and programmed cell death-ligand 1(PD-L1)in SMARCA4-deficient non-small cell lung cancer,and to provide a scientific basis for the study of the follow-up treatment of this rare pathological type of lung cancer.METHODS:The clinical and pathological characteristics of 12 patients with this disease were analyzed retrospectively,and the patients were divided into two groups of adenocarcinomas and poorly differentiated carcinomas according to their morphological characteristics,and the relationship between the expression of SPP1 and PD-L1 was analyzed in the two groups.RESULTS:SPP1 expression was detected in all patients and Its expression level was significantly higher in the poorly differentiated carcinoma group compared with the adenocarcinoma group(P=0.015);PD-L1 expression was found in 6/7 patients(5 cases were not measured),compared with the adenocarcinoma group,PD-L1 was also highly expressed in the poorly differentiated carcinoma group(P=0.048)and the PD-L1 difference between the two groups suggested that the results were similar to those of SPP1.CONCLUSION:SMARCA4-deficient non-small cell lung cancer has high positive expression of SPP1 and PD-L1.It was more pronounced in patients with poorly differentiated carcinoma.There may be a positive correlation between SPP1 and PD-L1 expression in SMARCA4-deficient non-small cell lung cancer and the mechanism of the correlation needs to be further verified in subsequent studies.

关 键 词：NSCLC SMARCA4缺失 SPP1 PD-L1 免疫治疗 

分 类 号：R965.2[医药卫生—药理学]