表观遗传学在抑郁症发病机制中的研究进展  

Research progress of epigenetics in the pathogenesis of depression

作　　者：张瑶 邹蔓姝 韩远山[2,3] 王宇红 ZHANG Yao;ZOU Manshu;HAN Yuanshan;WANG Yuhong(Technology Innovation Center,Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China;Hunan Provincial Key Laboratory of Prevention and Treatment of Depressive Diseases with Traditional Chinese Medicine,Changsha 410208,Hunan,China)

机构地区：[1]湖南中医药大学科技创新中心,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007 [3]抑郁类疾病中医药防治湖南省重点实验室,湖南长沙410208

出　　处：《中国临床药理学与治疗学》2025年第4期517-525,共9页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(82174357);湖南省中医药管理局科研项目(B2023141);湖南省科药联合基金(2023JJ60476);湖南省教育厅优秀青年基金(23B0360,24B0342);湖南中医药大学研究生创新课题(2024CX199)。

摘　　要：抑郁症是一种在世界范围内患病率不断上升的精神疾病,具有高致残率和高自杀率,严重危害人类健康。表观遗传学是21世纪新兴的遗传学说,其主要研究内容是在不涉及DNA序列改变的条件下,对基因转录或翻译的过程进行调控,影响其功能和特性。主要包括DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA调控。神经系统容易受到表观遗传修饰因子活性变化的影响,并且越来越多的研究表明遗传和环境在抑郁症发生发展中起重要作用。本文将围绕抑郁症的表观遗传学机制进行综述。Depression is a mental disease with increasing prevalence worldwide,which seriously endangers human health with high disability rate and high suicide rate.Epigenetics is an emerging genetic theory in the 21st century.Its main research content is to regulate the process of gene transcription or translation and affect its function and characteristics without changing the DNA sequence.These include DNA methylation,histone modification,chromatin remodeling and non-coding RNA regulation.The nervous system is susceptible to changes in the activity of epigenetic modifiers,and an increasing number of studies have shown that genetics and environment play an important role in the development of depression.This review will focus on the epigenetic mechanisms of depression.

关 键 词：抑郁症 表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA调控 染色质重塑 

分 类 号：R73[医药卫生—肿瘤]