以脑膜脑炎为主要表现的嗜酸性粒细胞增多症1例  

A case of eosinophilia presenting with meningoencephalitis

作　　者：吴双 张宸睿 毕莹 徐艳[1] 何丹 WU Shuang;ZHANG Chenrui;BI Ying;XU Yan;HE Dan(Department of Neurology,Zhongnan Hospital of Wuhan University,Wuhan 430000,China)

机构地区：[1]武汉大学中南医院神经内科,武汉430000

出　　处：《中国神经精神疾病杂志》2025年第2期109-111,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：武汉大学中南医院科技创新平台支撑项目(编号:PTXM2024016);武汉大学中南医院神经内科(武汉430000)。

摘　　要：本文报告1例嗜酸性粒细胞性脑膜脑炎的患者,表现为情绪低落、头痛及记忆力减退,查体可见精神紧张,言语稍含糊,认知功能减退。实验室检查提示外周血及脑脊液中嗜酸性粒细胞明显升高,考虑嗜酸性粒细胞增多性脑膜脑炎,给予糖皮质激素、改善认知功能等治疗后症状好转。回顾其临床特点、实验室检查资料及诊疗经过,探讨以脑膜脑炎为表现形式的嗜酸性粒细胞增多症的发病机制、治疗及鉴别,借此提高临床医师对嗜酸性粒细胞增多症并发脑膜脑炎的认识,为此类疾病提供临床诊疗参考。We reported a case of eosinophilic meningoencephalitis,presenting with symptoms such as depression,headache and memory decline.Physical examination revealed mental tension,slightly slurred speech,and cognitive decline.Laboratory tests indicated a significant increase in eosinophils in both peripheral blood and cerebrospinal fluid,suggesting eosinophilic meningoencephalitis.After treatment with glucocorticoids and cognitive function improvement measures,the patient’s symptoms improved.Here,we summarized its clinical features,laboratory examination,diagnosis and treatment.Then,we discussed the pathogenesis,treatment and differential diagnosis of eosinophilia manifested as meningoencephalitis.In order to improve clinicians’understanding of eosinophilia complicated with meningoencephalitis and provide reference for clinical diagnosis and treatment of these diseases.

关 键 词：嗜酸性粒细胞增多症 脑膜脑炎 认知功能下降 中枢神经系统感染 头痛 

分 类 号：R742[医药卫生—神经病学与精神病学] R557[医药卫生—临床医学]