T淋巴细胞亚群水平对急性淋巴细胞白血病患儿预后的影响分析  

Effect of T lymphocyte subsets on the prognoses of children with acute lymphoblastic leukemia

作　　者：张相梅 潘洪鑫 蒋焰 ZHANG Xiangmei;PAN Hongxin;JIANG Yan(Second Department of Pediatric Internal Medicine,Affiliated Hospital of Zunyi Medical University,Guizhou Children’s Hospital,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学附属医院、贵州省儿童医院小儿内二科,贵州遵义563000

出　　处：《医药前沿》2025年第10期16-19,共4页Journal of Frontiers of Medicine

摘　　要：目的分析T淋巴细胞亚群水平对急性淋巴细胞白血病(ALL)患儿预后的影响。方法选取2020年1月—2023年1月遵义医科大学附属医院收治的60例ALL患儿作为观察组,同期进行健康体检的健康儿童62例作为对照组。另外,观察组患儿在诱导化疗28 d后,根据病情缓解情况分为缓解组(38例)和未缓解组(22例)2个亚组。比较观察组诱导化疗前与对照组健康体检当天、观察组诱导化疗前和诱导化疗28 d后及缓解组和未缓解组患儿诱导化疗前和诱导化疗28 d后外周血T淋巴细胞亚群水平,以及随访12个月缓解组与未缓解组患儿病死和复发情况。结果观察组诱导化疗前CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平均低于对照组健康体检当天;诱导化疗28 d后,观察组CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平均高于诱导化疗前,差异有统计学意义(P<0.05)。诱导化疗28 d后,缓解组CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平高于诱导化疗前,未缓解组CD3^(+)、CD4^(+)和CD8^(+)水平低于诱导化疗前;缓解组CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平高于未缓解组,差异有统计学意义(P<0.05)。随访12个月,缓解组复发率低于未缓解组,差异有统计学意义(P<0.05);缓解组与未缓解组病死率比较,差异无统计学意义(P>0.05)。结论对于ALL患儿,通过监测诱导化疗前后T淋巴细胞亚群水平,有助于预测预后。Objective To analyze the effect of T lymphocyte subsets on the prognoses of children with acute lymphoblastic leukemia(ALL).Methods A total of 60 children with ALL admitted to the Affiliated Hospital of Zunyi Medical University from January 2020 to January 2023 were selected as the observation group,while 62 healthy children who underwent physical examination during the same period were selected as the control group.In addition,the children in the observation group were divided into remission subgroup(38 cases)and non-remission subgroup(22 cases)according to the remission conditions after induction chemotherapy for 28 days.The levels of peripheral blood T lymphocyte subsets were compared between the observation group before induction chemotherapy and the control group on the day of physical examination,before and after induction chemotherapy for 28 days in the observation group,before and after induction chemotherapy for 28 days in the remission subgroup and the non-remission subgroup,and the conditions of death and recurrence in the remission subgroup and the non-remission subgroup after 12 months of follow-up.Results In the observation group,the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)before induction chemotherapy were lower than those in the control group on the day of physical examination,while the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)after induction chemotherapy for 28 days were higher than those before induction chemotherapy,and the differences were statistically significant(P<0.05).After induction chemotherapy for 28 days,the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)were higher than those before induction chemotherapy in the remission subgroup,while the levels of CD3^(+),CD4^(+)and CD8^(+)were lower than those before induction chemotherapy in the non-remission subgroup,and the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in remission subgroup were higher than those in non-remission subgroup,and the differences were statistically significant(P<0.05).After 12 mont

关 键 词：淋巴细胞白血病 儿童 T淋巴细胞亚群 预后 诱导化疗 

分 类 号：R733[医药卫生—肿瘤]