氨磺必利联合草酸艾司西酞普兰治疗精神分裂症阴性症状的效果评价  

Efficacy evaluation of Amisulpride combined with Escitalopram Oxalate in the treatment of negative symptoms of schizophrenia

作　　者：杨天龙 马来福 YANG Tianlong;MA Laifu(Department of Psychiatry,Beijing Daxing District Xinkang Hospital,Beijing 102600,China;Department of Psychiatry,Beijing Huairou Anjia Hospital,Beijing 101408,China)

机构地区：[1]北京市大兴区心康医院精神科,北京102600 [2]北京市怀柔安佳医院精神科,北京101408

出　　处：《医药前沿》2025年第10期67-70,共4页Journal of Frontiers of Medicine

摘　　要：目的探讨氨磺必利联合草酸艾司西酞普兰治疗精神分裂症阴性症状的效果。方法选取2022年6月—2023年6月北京市大兴区心康医院收治的86例精神分裂症阴性症状患者,根据治疗方法不同分为观察组和对照组,各43例。对照组采取氨磺必利治疗,观察组采取氨磺必利联合草酸艾司西酞普兰治疗,治疗12周。比较两组阳性和阴性症状量表(PANSS)评分、PANSS阴性症状各维度评分、Stroop色词测验(SCWT)、个人与社会功能量表(PSP)评分、Matrics认知功能成套测试(MCCB)评分及不良反应。结果治疗4和12周后,观察组PANSS阳性症状、阴性症状评分及总分低于对照组,干扰命名、颜色命名、字词阅读、PSP评分、MCCB评分多于或高于对照组;治疗12周后,观察组刻板思维、交流缺乏自发性、抽象思维障碍、被动社交退缩、情感交流障碍、情绪退缩、情感迟钝各阴性症状评分低于对照组(P<0.05)。治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论氨磺必利联合草酸艾司西酞普兰治疗精神分裂症阴性症状效果显著,可促进康复。thinking disorder,passive social withdrawal,emotional communication disorder,emotional withdrawal,and affective flattening in the observation group were lower than those in the control group(P<0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Amisulpride combined with Escitalopram Oxalate is effective in treating negative symptoms of schizophrenia,promoting recovery.

关 键 词：氨磺必利 草酸艾司西酞普兰 精神分裂症 阴性症状 阳性和阴性症状量表 Stroop色词测验 个人与社会功能量表 

分 类 号：R749[医药卫生—神经病学与精神病学]