奥美拉唑联合内镜下止血治疗上消化道出血患者的效果观察  

Effect observation of Omeprazole combined with endoscopic hemostasis in the treatment of patients with upper gastrointestinal bleeding

作　　者：宋建强[1] 葛洁[1] SONG Jianqiang;GE Jie(Department of Gastroenterology,People's Hospital of Huantai County,Zibo,Shandong 256400,China)

机构地区：[1]桓台县人民医院消化内科,山东淄博256400

出　　处：《医药前沿》2025年第10期71-73,共3页Journal of Frontiers of Medicine

摘　　要：目的观察奥美拉唑联合内镜下止血治疗上消化道出血(UGIB)患者的效果。方法选取2018年1月—2021年12月桓台县人民医院收治的50例UGIB患者,采用随机数字表法分为观察组和对照组,各25例。对照组患者给予内镜下止血治疗,观察组患者于内镜下止血基础上加用奥美拉唑治疗。比较两组患者的临床疗效、临床指标、凝血功能指标[活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、纤维蛋白原(Fibrinogen,FIB)、凝血酶原时间(Prothrombin time,PT)、血小板(platelet,PLT)、D-二聚体]和炎症因子[肿瘤坏死因子-α(tumor necrosis factor alpha,TNF-α)、白细胞介素6(Interleukin-6,IL-6)、C反应蛋白(C reactive protein,CRP)]。结果治疗后,观察组临床总有效率高于对照组;观察组止血时间、住院时间短于对照组,输血量少于对照组,再出血率低于对照组;治疗后,观察组APTT、FIB、PT、D-二聚体、TNF-α、IL-6、CRP水平短于或低于对照组,PLT水平高于对照组(P<0.05)。结论在UGIB患者中应用奥美拉唑联合内镜下止血治疗效果显著,能够改善患者凝血功能,减轻机体内炎症反应,降低再出血率。Objective To observe the effect of Omeprazole combined with endoscopic hemostasis in the treatment of patients with upper gastrointestinal bleeding(UGIB).Methods From January 2018 to December 2021,50 patients with UGIB admitted to People's Hospital of Huantai County were randomly divided into two groups:an observation group and a control group,each consisting of 25 patients.Patients in the control group were treated with endoscopic hemostasis,while patients in the observation group were treated with Omeprazole on the basis of endoscopic hemostasis.The clinical efficacy,clinical indicators,coagulation function indicators[activated partial thromboplastin time(APTT),fibrinogen(FIB),prothrombin time(PT),platelet(PLT),D-dimer],and inflammatory factor[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C reactive protein(CRP)]were compared and analyzed between the two groups.Results After treatment,the total clinical efficacy rate in the observation group was higher than that in the control group;the hemostasis time and hospitalization time in the observation group were shorter than those in the control group,the blood transfusion volume was less,and the rebleeding rate was lower;after treatment,the levels of APTT,FIB,PT,D-dimer,TNF-α,IL-6,and CRP in the observation group were shorter or lower than those in the control group,while the PLT level was higher,with statistically significant differences(P<0.05).Conclusions The application of Omeprazole combined with endoscopic hemostasis in UGIB patients has significant therapeutic effects,improving coagulation function,reducing systemic inflammatory response,and lowering the rebleeding rate.

关 键 词：上消化道出血 内镜下止血 奥美拉唑 再出血 活化部分凝血活酶时间 肿瘤坏死因子-α 

分 类 号：R573[医药卫生—消化系统]