肺积丸联合TP方案治疗非小细胞肺癌临床效果观察  

Clinical effect observation of Feiji Pills combined with TP regimen in the treatment of non-small cell lung cancer

作　　者：尹智星 张金兰 毛毛[2] 焦宁[2] 谭国昌[2] 张亚男 秦越 徐雨 YIN Zhixing;ZHANG Jinlan;MAO Mao;JIAO Ning;TAN Guochang;ZHANG Yanan;QIN Yue;XU Yu(Department of Pulmonology,Zibo Hospital of Traditional Chinese Medicine,the Fourth Affiliated Hospital of Shandong University of Chinese Medicine,Zibo,Shandong 255000,China;Department of Oncology,Zibo Hospital of Traditional Chinese Medicine,the Fourth Affiliated Hospital of Shandong University of Chinese Medicine,Zibo,Shandong 255000,China)

机构地区：[1]山东中医药大学第四附属医院、淄博市中医院肺病科,山东淄博255000 [2]山东中医药大学第四附属医院、淄博市中医院肿瘤科,山东淄博255000

出　　处：《医药前沿》2025年第10期77-80,共4页Journal of Frontiers of Medicine

基　　金：山东省中医药科技项目(2021Q049)。

摘　　要：目的探讨肺积丸联合多西他赛和顺铂(TP)方案治疗非小细胞肺癌(NSCLC)的临床效果。方法选取2022年2月—2023年12月淄博市中医院收治的100例NSCLC患者,采用随机数字表法分为观察组和对照组,每组50例。对照组行TP方案治疗,观察组使用肺积丸联合TP方案治疗,21 d为1个疗程,两组均治疗4个疗程。比较两组临床效果、生存质量、肿瘤标志物水平、中医症候改善情况及不良反应发生情况。结果治疗后,观察组客观缓解率高于对照组,但两组比较差异无统计学意义(P>0.05)。治疗后,观察组生存质量提高率和中医证候改善率高于对照组;两组肿瘤标志物水平均较治疗前降低,且观察组低于对照组(P<0.05)。治疗期间,观察组轻中度和重度胃肠道反应和白细胞降低发生率低于对照组(P<0.05)。结论肺积丸联合TP方案治疗NSCLC患者与单行TP方案治疗比较临床效果基本相当,但可提高患者生存质量,改善临床症状和肿瘤标志物水平,且不良反应发生率较低。Objective To investigate the clinical effect of Feiji Pills combined with Docetaxel and Cisplatin(TP)regimen in the treatment of non-small cell lung cancer(NSCLC).Methods A total of 100 patients with NSCLC admitted to Zibo Hospital of Traditional Chinese Medicine from February 2022 to December 2023 were selected and divided into observation group and control group by random number table method,with 50 cases in each group.The control group was treated with TP regimen,and the observation group was treated with Feiji Pills combined with TP regimen.21 d was a course of treatment,and both groups were treated for 4 courses.The clinical effect,quality of life,tumor marker levels,improvement of traditional Chinese medicine symptomes and adverse reactions were compared between the two groups.Results After treatment,the objective remission rate of the observation group was higher than that of the control group,but there was no significant difference between the two groups(P>0.05).After treatment,the improvement rate of quality of life and traditional Chinese medicine syndromes in the observation group were higher than those in the control group.The tumor marker levels of the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).During the treatment,the incidence of mild to moderate and severe gastrointestinal reactions and leukopenia in the observation group was lower than that in the control group(P<0.05).Conclusions The clinical effect of Feiji Pills combined with TP regimen in the treatment of NSCLC patients is basically the same as that of single TP regimen,but it can improve the quality of life of patients,improve clinical symptoms and tumor marker levels,and the incidence of adverse reactions is low.

关 键 词：肺积丸 多西他赛 顺铂 非小细胞肺癌 治疗效果 生存质量 中医证候 不良反应 

分 类 号：R734[医药卫生—肿瘤]