REV-ERBs对头颈鳞状细胞癌的肿瘤调节作用  

Tumor regulatory effect of REV-ERBs on head and neck squamous cell carcinoma

作　　者：胡仿玲 桂誉淋 HU Fangling;GUI Yulin(Department of Otolaryngology Head and Neck Surgery,Women&Children′s Health Care Hospital of Linyi,Linyi,Shandong 276000,China;Department of Otolaryngology Head and Neck Surgery,Jiujiang NO.1 People′s Hospital,Jiujiang,Jiangxi 332000,China)

机构地区：[1]临沂市妇幼保健院耳鼻咽喉头颈外科,山东临沂276000 [2]九江市第一人民医院耳鼻咽喉头颈外科,江西九江332000

出　　处：《现代医药卫生》2025年第3期594-598,共5页Journal of Modern Medicine & Health

摘　　要：目的 探讨昼夜节律性核受体——REV-ERBs对头颈鳞状细胞癌(HNSCC)的肿瘤调节作用。方法 2020年5月采用CCK-8检测法、克隆形成实验、Transwell检测法、细胞划痕实验等检测REV-ERBs特异性受体激动剂——SR9009对HNSCC的细胞增殖、迁移和侵袭作用,通过体外药物敏感性检测SR9009对HNSCC的肿瘤抑制作用。结果 SR9009能明显抑制HNSCC的细胞增殖、迁移和侵袭,对HNSCC具有肿瘤抑制作用。结论 REV-ERBs的特异性受体激动剂——SR9009对HNSCC具有肿瘤抑制作用,通过对REV-ERBs的调节可达到抑制HNSCC的作用。Objective To explore the tumor regulatory effect of circadian nuclear receptors,REV-ERBs,on head and neck squamous cell carcinoma(HNSCC).Methods In May 2020,CCK-8 assay,clone formation assay,Transwell assay and cell scratch assay were used to detect the effects of REV-ERBs specific receptor agonist-SR9009 on cell proliferation,migration and invasion of HNSCC.The inhibitory effect of SR9009 on HNSCC was detected by in vitro drug sensitivity.Results SR9009 can significantly inhibit the proliferation,migration and invasion of HNSCC cells,and had a tumor suppressive effect on HNSCC.Conclusion SR9009,a specific receptor agonist of REV-ERBs,has a tumor suppressive effect on HNSCC,which can be achieved through the regulation of REV-ERBs.

关 键 词：头颈鳞状细胞癌 REV-ERBs SR9009 肿瘤抑制 

分 类 号：R739.91[医药卫生—肿瘤]