Bifidobacterium breve alleviates gut-liver-axis injury caused by high-fat diet and aflatoxin B_1 in mice  

作　　者：Yongli Ye Tingwei Wang Jian Ji Jia-Sheng Wang Yinzhi Zhang Xiulan Sun 

机构地区：[1]International Joint Laboratory on Food Safety,Synergetic Innovation Center of Food Safety and Quality Control,School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [2]School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023,China [3]Department of Environmental Health Science,College of Public Health,University of Georgia,Athens 30602,USA [4]Yixing Institute of Food and Biotechnology Co.,Ltd.,Yixing 214200,China

出　　处：《Food Science and Human Wellness》2025年第2期617-632,共16页食品科学与人类健康(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(32125031);the Fundamental Research Funds for the Central Universities(JUSRP222001);Collaborative Innovation Center for Food Safety and Quality Control,China。

摘　　要：Aflatoxin B_1(AFB_1)is a common contaminant in cereals of global concern,and long-term low-dose exposure can adversely affect human health.Here,we showed that populations with dietary patterns characterized by high-fat diet(HFD)might have an increased risk of exposure to high levels of AFB_1.Our data indicated that chronic exposure of AFB_1 induced“gut-liver axis”injury in mice under HFD and normal diet(ND)patterns.AFB_1 further aggravated hepatic and intestinal injury,and intestinal microbiota disruption in HFD mice.Bifidobacterium breve BAA-2849 intervention analysis showed that liver injury and lipid disorders caused by AFB_1 exposure were alleviated by regulating the proportions of different gut microbes.We demonstrated through a mice model that the populations with a dietary pattern of HFD might be more susceptible to AFB_1 exposure and adverse effects on the gut-liver axis,and the toxicity of AFB_1 exposure can be alleviated by regulating the gut microbiota.

关 键 词：Aflatoxin B_1 High-fat diet Lipid metabolism Gut-liver axis Gut microbiota Bifidobacterium breve 

分 类 号：R57[医药卫生—消化系统]