Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms  

作　　者：Jinhai Luo Weiqi Yan Zhi Chen Baojun Xu 

机构地区：[1]Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science,Department of Life Sciences,BNU-HKBU United International College,Zhuhai 519087,China [2]Centre for Cancer and Infl ammation Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong 999077,China [3]Faculty of Biochemistry and Molecular Medicine,University of Oulu,Oulu 90220,Finland

出　　处：《Food Science and Human Wellness》2025年第4期1224-1238,共15页食品科学与人类健康(英文)

基　　金：supported by the Guangdong Provincial Key Laboratory IRADS(2022B1212010006,R0400001-22)。

摘　　要：Obesity has become a significant global public health issue.Previous studies have found that the Chenpi has the anti-obesity activity.However,the anti-obesity phytochemicals and their mechanisms are still unclear.This study investigated the anti-obesity phytochemicals and molecular mechanisms involved in treating obesity by Chenpi through network pharmacology and molecular docking.A total of 17 bioactive phytochemicals from Chenpi and its 475 related anti-obesity targets have been identified.The KEGG pathway analysis showed that the PI3K/Akt signaling pathway,MAPK signaling pathway,AMPK signaling pathway,and nuclear factor kappa B signaling pathway are the main signaling pathways involved in the anti-obesity effect of Chenpi.According to molecular docking analysis,the phytochemicals of Chenpi can bind to central anti-obesity targets.Based on the ADMET analysis and network pharmacology results,tangeretin exhibited the lowest predicted toxicity and potential for anti-obesity effects.In the in vitro lipid accumulation model,tangeretin effectively suppressed the free fatty acid-induced lipid in Hep G2 cells by upregulating the PI3K/Akt/GSK3βsignaling pathway based on the result of q-PCR and Western blotting.The outcomes of this research give insights for future research on the anti-obesity phytochemicals and molecular mechanisms derived from Chenpi,also providing the theoretical basis for developing anti-obesity functional foods based on Chenpi.

关 键 词：Chenpi PHYTOCHEMICALS OBESITY Network pharmacology Molecular mechanism Signaling pathway 

分 类 号：R73[医药卫生—肿瘤]