Sturgeon cartilage-derived chondroitin sulfate exhibited anti-inflammatory activity against dextran sulfate sodium-induced colitis via modification of gut microbiota  

作　　者：Ruiyun Wu Zixin Han Zhenyu Wang Pinglan Li Nan Shang 

机构地区：[1]Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products,Ministry of Agriculture and Rural Affairs,Beijing 100193,China [2]Collage of Engineering,China Agricultural University,Beijing 100083,China [3]Collage of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China

出　　处：《Food Science and Human Wellness》2025年第4期1239-1250,共12页食品科学与人类健康(英文)

基　　金：funded by grants from Beijing Fishery Innovation Team Project(BAIC07-2023-13);National Natural Science Foundation of China(32201994)。

摘　　要：Chondroitin sulfate(CS)is one of the main bioactive compounds in animal cartilage.In this study,the antiinflammatory activity of sturgeon-derived chondroitin sulfate(SCS)was evaluated in the dextran sulfate sodium(DSS)-induced BALB/c mice model.Orally administration of SCS significantly alleviated the DSSinduced colitis symptoms,including the reduction of crypt depth,inhibition of the abnormal crypt foci formation,down-regulation of the proinflammatory biomarkers(NO,interleukin(IL)-6,IL-1βand tumor necrosis factor-α)and up-regulation of the anti-inflammatory biomarkers(IL-10 and IL-4).The gut microbiota analysis revealed that SCS alters the intestinal microbiota composition in colitis mice,especially the increase of the relative abundance of Ruminococcaceae and Lachnospiraceae.This alternation further induced primary bile acids convert into secondary bile acids.With SCS administration,the levels of deoxycholic acid(DCA)and litho cholic acid(LCA)were increased by 1.5-and 2.5-fold,respectively.The stimulated secretion of DCA and LCA showed further activation of the NF-κB signaling pathway,thereby suppressing the inflammatory response and attenuating inflammatory bowel disease(IBD)in mice.This study provided a valuable strategy for colitis prevention and treatment with sturgeon cartilage by-products.

关 键 词：Sturgeon cartilage Chondroitin sulfate Anti-inflammatory activity Dextran sulfate sodium-induced colitis Gut microbiota 

分 类 号：TS254.9[轻工技术与工程—水产品加工及贮藏工程]