The antioxidant,antidiabetic,and antihyperlipidemic effects of the polyphenolic extract from Salvia blancoana subsp.mesatlantica on induced diabetes in rats  

作　　者：Souad Maache Hassan Laaroussi Najoua Soulo Ghizlane Nouioura Nabil Boucetta Mohammed Bouslamti Hamza Saghrouchni Yousef A.Bin Jardan Samir Ibenmoussa Mohammed Bourhia Badiaa Lyoussi Ilham Elarabi 

机构地区：[1]Laboratory of Natural Substances,Pharmacology,Environment,Modeling,Health,and Quality of Life(SNAMOPEQ),Faculty of Sciences Dhar El Mahraz,Sidi Mohamed Ben Abdellah University,Fez,Morocco [2]Medical Analysis Labo-ratory Sais,Fez,Morocco [3]Department of Biotechnology,Institute of Natural and Applied Sciences,Çukurova University,01250,Balcalı,Adana,Türkiye [4]Department of Pharmaceutics,College of Pharmacy,King Saud University,P.O.Box 11451,Riyadh,Saudi Arabia [5]Laboratory of Therapeutic and Organic Chemistry,Faculty of Pharmacy,University of Montpellier,34000 Montpellier,France [6]Laboratory of Biotechnology and Natural Resources Valorization,Faculty of Sciences,Ibn Zohr University,80060 Agadir,Morocco [7]Laboratory of Chemistry-Biochemistry,Environment,Nutrition,and Health,Faculty of Medicine and Pharmacy,University Hassan II,B.P.5696,Casablanca,Morocco.

出　　处：《Bioresources and Bioprocessing》2024年第1期835-853,共19页生物资源与生物加工(英文)

基　　金：financially supported by the Researchers Supporting Project(RSP2024R457).King Saud University,Riyadh,Saudi Arabia.

摘　　要：Currently,several studies have demonstrated the benefits of medicinal plants in managing type 2 diabetes.In this work,we evaluated the beneficial effects of the polyphenolic extract(PESB)from Salvia blancoana subsp.mesatlan-tica in the management of hypercaloric-feeding and small-dose alloxan-brought type 2 diabetes in rats.We analyzed the chemical constituents of the extract,including flavones and flavonols content,to understand its biological action.The antioxidant activities were evaluated by total antioxidant action,scavenging effect of the free radical DPPH,and reducing power.The obtained results showed that the value of TFC was estimated at 31.90±0.34 mgEQ/g in the PESB extract.The total antioxidant capacity was estimated at 593.51±4.09 mg(EAA)/g,the value of DPPH IC50 was 7.3±0.00μg/mL,and the value of EC50 of reducing power was estimated at 6.43±0.01μg/mL.In total,14 phenolic compounds were identified and the naringin was the most dominant(63.19%)while the vanillin was the less recorded(0.10%).Serum glucose decreased significantly(p<0.05)in rats given PESB(100 mg/kg)after four weeks.Glibenclamide(GLB)and PESB reduced HbA1c and increased plasma insulin in diabetic rats,restoring HOMA-βand HOMA-IR levels to near-normal.Additionally,diabetic rats treated with GLB or PESB showed statistically equivalent results to those of non-diabetic rats regarding hepatic enzymes,renal and lipid markers,as well as cardiovascular indices.The weight loss was significantly lower in diabetic rats receiving a dose of PESB(100 mg/kg),and GLB compared to corresponding untreated diabetic rats(p<0.01).PESB and GLB showed a prominent protective function in the pancreas,liver,and kidney tissues.This investigation demonstrates the capacity of extracts from leaves of S.blancoana subsp.mesatlantica to manage diabetes mellitus due to their richness in a wide range of bioactive compounds.Therefore,more investigations are required to estimate the safety of the plant use.

关 键 词：ANTI-DIABETIC ANTIOXIDANT EXTRACT Chemical compounds Salvia blancoana subsp.mesatlantica 

分 类 号：R58[医药卫生—内分泌]