Altitude adaptation:The unseen work of gut microbiota  

作　　者：Jingling Guo Runzhou Zhao Kun Li Yafang Tan Likun Wang Hui Ling Huan Zhang Guha Dharmarajan Yujing Bi Ruifu Yang 

机构地区：[1]State Key Laboratory of Pathogen and Biosecurity,Academy of Military Medical Sciences,Beijing,China [2]School of Public Health,Hebei Medical University,Hebei,China [3]Division of Sciences,School of Interwoven Arts and Sciences,Krea University,Andhra Pradesh,India

出　　处：《hLife》2025年第1期5-20,共16页微生物与宿主健康(英文)

基　　金：supported by the National Natural Science Foundation for Key Programs of China Grants(No.32394054);the National Key R&D Program of China(No.2022YFC2601200).

摘　　要：High altitudes are one type of extreme environment characterized by hypobaric hypoxia,extreme cold,strong ultraviolet radiation,and low energy availabilty that present tremendous challenges to human and wildlife inhabiting these environs.These extreme environments serve as a unique natural laboratory for delving into the impact of selective pressures on species variation and adaptation.This narrative review compiles the latest research on high-altitude adaptation,with a specific focus on the crucial role of gut microbiota in this process.Evidence indicates that gut microbiota significantly impacts an organism’s ability to adapt to high-altitude conditions by adjusting its composition,and hence impacting its function and ability to release microbial metabolites.We explore the link between gut microbiota and highaltitude environments,the microbial signatures,and their effects on adaptation,as well as the potential for targeted modulation of gut microbiota to enhance acclimatization to high altitudes.By examining the interaction between microbiota and host adaptation,this review aims to promote further mechanistic studies and support strategies for improving high-altitude acclimatization through gut microbiota modulation.

关 键 词：PLATEAU gut microbiota hypobaric hypoxia highland exposure ACCLIMATIZATION 

分 类 号：R57[医药卫生—消化系统]