具核梭形杆菌对食管癌发生发展及治疗转归的影响  

The role of Fusobacterium nucleatum on the emergence,progression,and treatment outcomes of esophageal cancer

作　　者：陆冰啸 龚晓宇 左相曾 吴娜[1] 龚成树 赵娟 李云霞[1] 吕东津[4] Lu Bingxiao;Gong Xiaoyu;Zuo Xiangzeng;Wu Na;Gong Chengshu;Zhao Juan;Li Yunxia;Lyu Dongjin(Department of Medical Oncology,the Third Affiliated Hospital of Kunming Medical University(Tumor Hospital of Yunnan Province),Kunming 650000,Yunnan,China;Department of Hepatobiliary Surgery,Affiliated Hospital of Kunming University of Science and Technology(the First People's Hospital of Yunnan Province),Kunming 650000,Yunnan,China;Department of Radiation Oncology,the Third Affiliated Hospital of Kunming Medical University(Tumor Hospital of Yunnan Province),Kunming 650000,Yunnan,China;Department of Clinical Research,National Institute for Drug Clinical Trails,the Third Affiliated Hospital of Kunming Medical University(Tumor Hospital of Yunnan Province),Kunming 650000,Yunnan,China)

机构地区：[1]昆明医科大学第三附属医院暨云南省肿瘤医院肿瘤内科,云南昆明650000 [2]昆明理工大学附属医院暨云南省第一人民医院肝胆胰外科,云南昆明650000 [3]昆明医科大学第三附属医院暨云南省肿瘤医院放射治疗科,云南昆明650000 [4]昆明医科大学第三附属医院暨云南省肿瘤医院国家药物临床实验机构临床研究部,云南昆明650000

出　　处：《消化肿瘤杂志(电子版)》2025年第1期78-83,共6页Journal of Digestive Oncology(Electronic Version)

基　　金：云南省教育厅科学研究基金项目(2024J0255);昆明医科大学研究生创新基金(2024S346)。

摘　　要：食管癌是全球范围内最常见的恶性肿瘤之一,严重危害人类健康。具核梭形杆菌是一种常见的革兰氏阴性厌氧菌,与多种疾病相关。近年来,具核梭形杆菌被发现与食管癌密切相关,可通过诱导癌症相关基因的表达、干扰多胺代谢、促进炎症因子的释放、调控免疫微环境等机制促进食管癌的发展,还可以通过降低机体免疫防御功能、诱导DNA损伤、诱导自噬体形成等机制导致食管癌患者对化疗及免疫药物的耐药。靶向具核梭形杆菌的治疗可能提供一种潜在的抗肿瘤方法,从而改善患者的预后。因此,本文就具核梭形杆菌在食管癌发生发展、化疗及免疫治疗中的作用和机制进行总结。Esophageal cancer ranks among the most prevalent malignant tumors globally,posing a significant threat to human health.Fusobacterium nucleatum(Fn),a common gram-negative anaerobic bacterium,has been linked to various diseases.Recently,Fn has been found to be playing a pivotal role in esophageal cancer development.This association is attributed to its ability to induce the expression of cancer-related genes,disrupt polyamine metabolism,stimulate the release of inflammatory factors,and modulate the immune microenvironment,among other mechanisms.Furthermore,Fn can diminish the body's immune defense capabilities,induce DNA damage,and promote autophagosome formation,thereby rendering esophageal cancer patients resistant to chemotherapy and immunotherapy drugs.Targeted therapy against Fn may present a promising anti-tumor strategy,potentially enhancing patient outcomes.This article provides a comprehensive overview of the role and mechanisms of Fn in the onset,progression,chemotherapy,and immunotherapy of esophageal cancer.

关 键 词：具核梭形杆菌 食管癌 作用机制 治疗反应 

分 类 号：R735.1[医药卫生—肿瘤]