ACSS2:Tumor-promoting lactyl-CoA synthetase that drives histone lactylation  

作　　者：Katherine L.Wang Zhongsheng You 

机构地区：[1]St.Agnes Academy,Texas,USA [2]Department of Cell Biology and Physiology,Washington University School of Medicine,St.Louis,Missouri,USA

出　　处：《hLife》2025年第3期118-120,共3页微生物与宿主健康(英文)

摘　　要：Lactate,a product of aerobic glycolysis,is frequently elevated in tumor cells due to the Warburg effect and frequent hypoxia[1].This functionally versatile molecule not only serves as a critical energy source and a building block for gluconeogenesis but also acts as a signaling molecule,regulating many cellular functions[2].Furthermore,lactate can be converted into lactyl-coenzyme A(CoA),which then donates the lactyl group for the lactylation of lysine residues in proteins such as histones to regulate protein interactions and functions[3].

关 键 词：ELEVATED frequent VERSATILE 

分 类 号：R73[医药卫生—肿瘤]