lncRNA SNHG12在老年乳腺癌中的表达及其与临床病理参数、预后的相关性分析  

Expression of lncRNA SNHG12 in breast cancer tissues of elderly patients and its correlation with clinicopathological parame-ters and prognosis

作　　者：席腾 李红涛 Xi Teng;Li Hongtao(Department of Thyroid and Breast Surgery,Jiaozuo Peoples Hospital Affiliated to Xinxiang Medical College,Jiaozuo,Henan,454000,P.R.China)

机构地区：[1]新乡医学院附属焦作市人民医院乳腺甲状腺外科,河南焦作454000

出　　处：《老年医学与保健》2025年第1期36-41,共6页Geriatrics & Health Care

摘　　要：目的分析长链非编码RNA小核仁RNA宿主基因12(lncRNA SNHG12)在老年乳腺癌中的表达及其与临床病理参数、预后的相关性。方法选取2019年4月—2021年5月焦作市人民医院行乳腺癌手术患者标本76例,包括癌组织和癌旁组织(癌周5 cm范围)。实时荧光定量聚合酶链式反应(RT-PCR)检测癌组织和癌旁组织中lncRNA SNHG12水平,分析lncRNA SNHG12与乳腺癌临床病理参数的关系;患者均进行3年有效随访,统计肿瘤复发、转移及患者死亡情况;采用Kaplan-Meier生存曲线分析lncRNA SNHG12差异表达对老年乳腺癌患者预后的影响;采用Cox回归分析老年乳腺癌预后的相关因素。结果癌组织中lncRNA SNHG12相对表达量高于癌旁组织[(1.98±0.23),vs(0.65±0.07),t=48.227,P<0.05]。lncRNA SNHG12在老年乳腺癌中表达水平与肿瘤最大径、淋巴结转移和ER有关(P<0.05)。Cox回归分析结果显示,肿瘤最大径>2 cm(OR=3.337,95%CI=1.167~9.541)、有淋巴结转移(HR=3.031,95%CI=1.282~7.167)、ER阴性(HR=4.702,95%CI=1.098~20.132)、lncRNA SNHG12高表达(HR=3.762,95%CI=1.339~10.569)是影响患者预后的独立危险因素(P<0.05)。lncRNA SNHG12高表达组3年生存率低于低表达组(70.59%vs 90.48%)(Log-rankχ2=5.614,P=0.017)。结论老年乳腺癌组织中lncRNA SNHG12表达可能高于癌旁组织,lncRNA SNHG12差异表达与多种临床病理参数可能有关,可望作为老年乳腺癌患者不良预后的重要指标。Objective To analyze the expression of long non-coding RNA small nucleolar RNA host gene 12(lncRNA SNHG12)in breast cancer tissues of elderly patients and its correlation with clinicopathological parameters and prognosis.Methods A total of 76 specimens of breast cancer tissue and paired adjacent tissues(within 5 cm of the tumor margin)were collected from elderly patients who underwent breast cancer surgery in Peoples Hospital of Jiaozuo City between April 2019 and May 2021.Real-time quantitative polymerase chain reaction(RT-PCR)was used to detect lncRNA SNHG12 levels in cancer and adjacent tissues.The relationship between lncRNA SNHG12 expression and clinicopathological parameters was analyzed.All patients were effectively followed up for 3 years.The recurrence,metastasis and death of patients were analyzed.KaplanMeier survival curves were used to assess the effects of lncRNA SNHG12 differential expression on prognosis,and Cox regression analysis was performed to identify prognostic factors.Results The relative expression of lncRNA SNHG12 was significantly higher in cancer tissues than that in adjacent tissues[(1.98±0.23)vs(0.65±0.07),t=48.227,P<0.05].The expression level of lncRNA SNHG12 was correlated with maximum tumor diameter,lymph node metastasis,and estrogen receptor(ER)(P<0.05).Cox regression analysis showed that maximum tumor diameter>2 cm(HR=3.337,95%CI=1.167-9.541),lymph node metastasis(HR=3.031,95%CI=1.282-7.167),ER negativity(HR=4.702,95%CI=1.098-20.132),and high expression of lncRNA SNHG12(HR=3.762,95%CI=1.339-10.569)were independent risk factors for poor prognosis(P<0.05).The 3-year survival rate was lower in the lncRNA SNHG12 high-expression group than that in the low-expression group(70.59%vs 90.48%;Log-rank c2=5.614,P=0.017).Conclusion The expression of lncRNA SNHG12 in breast cancer tissues of elderly patients may be higher than that in adjacent tissues.The differential expression of lncRNA SNHG12 may be related to a variety of clinicopathological parameters,and may be used as an important in

关 键 词：老年 乳腺癌 长链非编码RNA SNHG12 临床病理特征 预后 

分 类 号：R73[医药卫生—肿瘤]