质谱成像技术在中药分析领域中的研究与应用  

Research and application of mass spectrometry imaging technology in traditional Chinese medicine analysis

作　　者：申夺 闵建新[1] 陈杰[1] 颜冬梅[1] 刘会会[2] 李斌[1] 聂宗秀[2] Duo Shen;Jianxin Min;Jie Chen;Dongmei Yan;Huihui Liu;Bin Li;Zongxiu Nie(Academician Workstation,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Key Laboratory of Analytical Chemistry for Living Biosystems,Institute of Chemistry,Chinese Academy of Sciences,Beijing National Laboratory for Molecular Sciences,Beijing 100190,China)

机构地区：[1]江西中医药大学院士工作站,南昌330004 [2]中国科学院化学研究所活体分析化学重点实验室,北京分子科学国家实验室,北京100190

出　　处：《中国科学:化学》2025年第3期661-677,共17页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:82260761,81760708);中央重大增减支项目(编号:2060302-2101-11,2060302-2101-10);院士工作站项目(编号:YSGZZ201801)资助。

摘　　要：中药的化学成分复杂且存在多成分、多途径、多靶点协同作用的机制,解析中药是一个很大的挑战.质谱成像是一种将质谱与离子成像相结合的技术,无需复杂的样品预处理过程,效率高、特异性强,且保留了物质的空间分布特征.作为一种原位可视化代谢物分布的工具,质谱成像技术被广泛用于中药研究.本文概述了在中药分析领域常用的质谱成像技术的原理与适用类型,总结其在中药活性成分的合成途径研究、中药质量控制研究、中药药理毒理机制研究等方面的应用,同时指出其存在的问题,以期质谱成像技术在中药分析领域中的进一步应用.Traditional Chinese medicine(TCM)contains complex chemical components that are difficult to separate,making the analysis of TCM a significant challenge.Mass spectrometry imaging(MSI)is a technology that combines mass spectrometry with ion imaging,requiring no complex sample pretreatment,and is highly efficient and specific while preserving the spatial distribution characteristics of the substances.As a non-destructive tool for in situ visualization of metabolite distribution,MSI has been widely used in TCM research in recent years.This review outlines the principles of commonly used MSI techniques in the field of TCM analysis,summarizes its applications in studying the synthesis pathways of active components,quality control of TCM,and the pharmacological and toxicological mechanisms of TCM,and points out existing problems,aiming to the further application of MSI technology in TCM analysis.

关 键 词：质谱成像 中药分析 活性成分 质量控制 药理机制 

分 类 号：R284.1[医药卫生—中药学] O657.63[医药卫生—中医学]