膳食维生素E摄入与前列腺癌风险:一项横断面研究和孟德尔随机化分析  

Dietary vitamin E intake and prostate cancer risk:a cross-sectional study and Mendelian randomisation analysis

作　　者：程龙 仇泽铭 董治龙[1] Cheng Long;Qiu Zeming;Dong Zhilong(Department of Urology,The Second Hospital of Lanzhou University,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第二医院泌尿外科,甘肃兰州730030

出　　处：《中国男科学杂志》2025年第1期118-126,137,共10页Chinese Journal of Andrology

基　　金：甘肃省科技厅联合科研基金一般项目(23JRRA1509)。

摘　　要：目的评估维生素E摄入量与罹患前列腺癌风险之间的因果关系。方法利用美国国家健康与营养调查(NHANES)2003—2010年的数据开展了一项观察性研究。采用加权多元线性回归分析,对三个不同的协变量进行了模型调整。根据年龄、种族和体重指数对亚组进行了进一步分层。采用基于全基因组关联研究的双样本孟德尔随机化(Mendelian randomization,MR)分析来推断因果关系。结果维生素E摄入量与罹患前列腺癌之间没有明显关联。利用主要遗传工具进行的MR分析也不支持维生素E摄入量与罹患前列腺癌风险之间存在因果关系(IVW:OR=1.001,95%CI:0.998-1.005)。结论本研究并不支持维生素E摄入量与罹患前列腺癌风险之间存在因果关系。Objective To calrify the causal relationship between vitamin E intake and prostate cancer risk.Methods Firstly,an observational study was conducted using data from National Health and Nutrition Examination Survey(NHANES)2003-2010.Weighted multiple linear regression was applied and a model adjusted for three different covariates was done.Subgroups were further stratified based on age,race,and BMI.Secondly,a two-sample Mendelian randomization(MR)analysis based on publicly available genome-wide association studies was employed to determine the causal relationship.Results There was no significant association between vitamin E intake and prostate cancer.Also,MR analyses with primary genetic instruments did not support a causal association between vitamin E intake and prostate cancer risk(IVW:OR=1.001,95%CI:0.998-1.005).Conclusion Our study did not support a causal association between vitamin E intake and prostate cancer risk.

关 键 词：维生素E 前列腺肿瘤 NHANES 孟德尔随机化 

分 类 号：R737.25[医药卫生—肿瘤]