蛋白质精氨酸甲基转移酶6在炎症相关疾病中的研究进展  

Research progress of protein arginine methyltransferase 6 in inflammation-related diseases

作　　者：黄智道 黎力 沃吟晴 韩超峰 孙琳琳 熊俊 Huang Zhidao;Li Li;Wo Yinqing;Han Chaofeng;Sun Linlin;Xiong Jun(Department of Histology and Embryology,College of Basic Medical Sciences,Naval Medical University,Shanghai 200433;Department of Pathology,Faculty of Medical Imaging,Naval Medical University,Shanghai 200433;Department of Human Anatomy,College of Basic Medical Sciences,Naval Medical University,Shanghai 200433;Department of Nephrology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China)

机构地区：[1]海军军医大学基础医学院组织学胚胎学教研室,上海200433 [2]海军军医大学影像医学系病理学教研室,上海200433 [3]海军军医大学基础医学院人体解剖学教研室,上海200433 [4]上海交通大学医学院附属同仁医院肾内科,上海200336

出　　处：《解剖学杂志》2025年第1期60-64,共5页Chinese Journal of Anatomy

基　　金：国家自然科学基金(32170878);上海市自然科学基金(20ZR1451600);上海市卫生和健康委员会科研项目(201940439)。

摘　　要：蛋白质精氨酸甲基转移酶6(PRMT6)是可催化蛋白质底物上精氨酸残基产生单甲基化和非对称双甲基化的Ⅰ型PRMT家族成员之一,存在与其他Ⅰ型PRMT家族成员不完全相同的催化结构,且与其他Ⅰ型PRMT家族成员的催化底物有所差异。越来越多的研究显示,PRMT6不仅在肿瘤进程中发挥重要作用,而且在炎症过程中起到调节剂的作用。现就PRMT6的催化结构和催化作用以及在抗器官炎症反应和促器官炎症反应中的研究进展作一综述。Protein arginine methyltransferase 6(PRMT6)is one of the typeⅠPRMT family members which catalyzes the monomethylation and asymmetric dimethylation of arginine residues on protein substrates.It has a catalytic structure that is not completely identical to other typeⅠPRMT family members,and exhibits differences in catalytic substrates.An increasing number of studies have reported that PRMT6 not only plays an important role in the tumor process,but also serves as a regulator in the inflammatory process.This article aims to review the catalytic structure and function of PRMT6,as well as the research progress on its role in both anti-inflammatory and pro-inflammatory responses in organs.

关 键 词：甲基转移酶 蛋白质精氨酸甲基转移酶6 炎症 

分 类 号：R363[医药卫生—病理学]