糖代谢重编程调控炎症反应的研究进展  

Research progress on regulation of inflammatory response by glucose metabolic reprogramming

作　　者：付庭吕 熊锐 李宁[1] 耿庆[1] FU Tinglyu;XIONG Rui;LI Ning;GENG Qing(Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胸外科,武汉430060

出　　处：《中国免疫学杂志》2025年第3期709-713,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金(81770095,82102269);中央高校基本科研专项基金(2042021kf0081);湖北省自然科学基金创新群体项目(2020CFA027)。

摘　　要：炎症反应是多种急慢性疾病的共同特征,涉及多种类型细胞的激活。与肿瘤细胞类似,炎症反应也受糖代谢重编程的调控。参与促炎反应的细胞,如M1型巨噬细胞、Th1和Th17淋巴细胞等通过糖代谢重编程将代谢途径转化为糖酵解,迅速产能刺激炎症的发生,而参与免疫调节和抗炎反应的细胞,如调节性T细胞和M2型巨噬细胞则优先利用脂肪酸氧化或氧化磷酸化产能。本文系统地综述了糖代谢重编程对炎症反应不同阶段的作用,以及糖代谢重编程在炎症反应中的多种分子机制,包括信号通路的激活或抑制、表观遗传调控、转录后调控和翻译后修饰,旨为深入探究糖代谢重编程对炎症反应的具体调控机制及炎症相关性疾病的治疗靶点提供参考。Inflammatory response is a common feature of many acute and chronic diseases,which involves in activation of various cell types.Similar to tumor cells,inflammatory response is regulated by glucose metabolic reprogramming.Cells involved in pro-inflammatory response,such as M1 macrophages,Th1 and Th17 lymphocytes,must generate energy rapidly through glycolysis transformed by glucose metabolic reprogramming to promote inflammation,while cells involved in immune regulation and anti-inflammatory response,such as regulatory T cells and M2 macrophages,preferentially use fatty acid oxidation and oxidative phosphorylation as a main source for energy production.This article systematically reviews the role of glucose metabolic reprogramming in different stages of inflammatory response,as well as the various molecular mechanisms of glucose metabolic reprogramming in inflammatory response,including activation or inhibition of signaling pathways,epigenetic regulation,post-transcriptional regulation and post-translational modification,which aims to provide a reference for exploring the specific regulatory mechanisms of glucose metabolic reprogramming on inflammatory response and the therapeutic targets of inflammatory-related diseases.

关 键 词：糖代谢重编程 炎症反应 代谢中间产物 表观遗传调控 转录后调控 翻译后修饰 

分 类 号：R364.5[医药卫生—病理学]