幽门螺杆菌对胃癌免疫检查点抑制剂疗效影响的研究进展  

Research progress on effect of Helicobacter pylori on immune checkpoint inhibitors of gastric cancer

作　　者：李麻图 郑亚 赵进玉 舒小闯 李强[2,3] 王玉平[2,3] 周永宁[2,3] LI Matu;ZHENG Ya;ZHAO Jinyu;SHU Xiaochuang;LI Qiang;WANG Yuping;ZHOU Yongning(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,the First Hospital of Lanzhou University,Lanzhou 730000,China;Clinical Medical Research Center of Digestive Diseases of Gansu Province,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院消化科,兰州730000 [3]兰州大学第一医院,甘肃省消化系疾病临床医学研究中心,兰州730000 [4]兰州大学第一医院普外科,兰州730000

出　　处：《中国免疫学杂志》2025年第3期727-732,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(71964021);兰州大学第一医院院内基金项目(ldyyyn2021-8,ldyyyn2021-59)。

摘　　要：胃癌是侵袭性强、转移率高的消化系统恶性肿瘤,发病率和病死率均居世界前五,其预后与疾病分期密切相关,晚期或转移性胃癌多采取以全身抗肿瘤治疗为主的多学科综合治疗,但预后普遍较差。随着对肿瘤微环境研究的深入、多组学技术的发展以及免疫治疗和新辅助放化疗的应用,晚期胃癌的治疗效果已得到初步改善,免疫治疗也因此成为最有潜力的治疗策略之一。研究发现幽门螺杆菌(Hp)感染状态与胃癌免疫治疗,尤其免疫检查点抑制剂(ICIs)的疗效关系密切,但其对免疫治疗效果的利弊尚无定论。本文就Hp对晚期胃癌的ICIs疗效的相关研究进行综述。Gastric cancer is a malignant tumor of the digestive system with strong invasiveness and a high metastasis rate.Its morbidity and mortality rank among the top five in the world and the prognosis is closely related to the disease stage.Multidisciplinary comprehensive treatment based on systemic antitumor drugs is generally adopted in patients with advanced or metastatic gastric cancer,but the prognosis is typically poor.With the in-depth research on the tumor microenvironment,the development of multi-omics technology,and the application of immunotherapy and neoadjuvant chemoradiotherapy,the therapeutic effect of advanced gastric cancer has been initially improved,and immunotherapy has become the most potential of the treatment strategies.Many studies have found that Helicobacter pylori(Hp)infection status is closely related to the efficacy of immunotherapy for gastric cancer,especially immune checkpoint inhibitors(ICIs),but there is not clear whether it has advantages or disadvantages.This article reviews the current research on the efficacy of Hp on ICIs in advanced gastric cancer to provide ideas for further research on the interaction between Hp infection and tumor immunotherapy.

关 键 词：胃癌 幽门螺杆菌 免疫检查点抑制剂 PD-1/PD-L1 免疫治疗 

分 类 号：R73[医药卫生—肿瘤]