注射用盐酸川芎嗪联合龙心素胶囊对脑梗死恢复期患者血液流变学及神经功能的影响  

The effect of ligustrazine hydrochloride for injection combined with Longxinsu capsules on hemorheology and neurological function in patients with cerebral infarction in the convalescent period

作　　者：李影[1] 张可[1] LI Ying;ZHANG Ke(Jiujiang NO.1 People′s Hospital,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院,332000

出　　处：《临床合理用药》2025年第9期1-4,9,共5页Chinese Journal of Clinical Rational Drug Use

基　　金：江西省卫生健康委科技计划项目(202211782)。

摘　　要：目的观察注射用盐酸川芎嗪联合龙心素胶囊对脑梗死恢复期患者血液流变学及神经功能的影响。方法选取2023年1月—2024年6月九江市第一人民医院收治脑梗死恢复期患者140例,根据病历尾号不同分为联合用药组与龙心素组,各70例。在常规对症治疗基础上,龙心素组予以龙心素胶囊,联合用药组在龙心素组基础上联用注射用盐酸川芎嗪。2组均以2周为1个疗程,持续治疗2个疗程。比较2组临床疗效,治疗前后血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度、血细胞比容)、血流动力学指标[双侧大脑中动脉峰流速(Vp)、双侧大脑中动脉平均流速(Vm)及其对称性差值(DVp、DVm)]、美国国立卫生院卒中量表(NIHSS)评分与日常生活能力量表(ADL)评分,不良反应。结果联合用药组治疗总有效率高于龙心素组(97.14%vs.85.71%,χ^(2)=5.833,P=0.016)。治疗2个疗程后,2组全血高切黏度、全血低切黏度、血浆黏度、血细胞比容降低,且联合用药组低于龙心素组(P<0.01);2组Vp、Vm加快,DVp、DVm降低,且联合用药组加快/降低幅度大于龙心素组(P<0.01);2组NIHSS评分降低,ADL评分升高,且联合用药组升高/降低幅度大于龙心素组(P<0.01)。联合用药组与龙心素组不良反应总发生率比较,差异无统计学意义(14.29%vs.11.43%,χ^(2)=0.255,P=0.614)。结论脑梗死恢复期患者在常规治疗基础上予以注射用盐酸川芎嗪联合龙心素胶囊治疗可有效改善患者血液流变学、血流动力学,从而改善生活能力,恢复神经功能,对患者疗效较好且安全可靠。Objective To observe the effect of ligustrazine hydrochloride for injection combined with Longxinsu capsules on hemorheology and neurological function in patients with cerebral infarction in the convalescent period.Methods One hundred and forty cases of patients with cerebral infarction in the convalescent period admitted to Jiujiang NO.1 People′s Hospital from January 2023 to June 2024 were selected,and were divided into the combined drug group and the Longxinsu group according to the different end numbers of the medical records,each with 70 cases.On the basis of conventional treatment,the Longxinsu group was given Longxinsu capsules,and the combined drug group was given ligustrazine hydrochloride for injection on the basis of Longxinsu group.Both groups were treated for 2 weeks as 1 course of treatment and continued for 2 courses of treatment.The clinical efficacy,hemorheology indexes(whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,hematocrit),hemodynamic indexes(Vp,Vm,DVp,DVm),NIHSS scores and ADL scores before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the combined drug group was higher than that in the Longxinsu group(97.14%vs.85.71%,χ^(2)=5.833,P=0.016).After two courses of treatment,the whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,hematocrit in the two groups decreased,and the combined drug group were lower than those in the Longxinsu group(P<0.01);The Vp and Vm in the two groups accelerated,while the DVp and DVm decreased,and the combined drug group were faster/lower than those in the Longxinsu group(P<0.01);The NIHSS score decreased and the ADL score increased in the two groups,and the combined drug group were higher/lower than those in the Longxinsu group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the combined drug group and the Longxinsu group(14.29%vs.11.43%,χ^(2)=0.255,P=0.614).Conclusion On

关 键 词：脑梗死 恢复期 注射用盐酸川芎嗪 龙心素胶囊 血液流变学 血流动力学 神经功能 

分 类 号：R74[医药卫生—神经病学与精神病学]